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Describe the application status of different immunochemotherapies in small B-cell non-Hodgkin lymphoma (iNHL), observe the therapeutic efficacy and safety of the treatment modalities.
Evaluated the efficacy and safety of different immunochemotherapies in small B-cell non-Hodgkin lymphoma (iNHL)
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| iNHL | Different immunochemotherapies in small B-cell non-Hodgkin lymphoma |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| immunochemotherapies | Drug | Observing different immunochemotherapies in small B-cell non-Hodgkin lymphoma (iNHL), which are chosen by investigators, such as RCHOP, BR, RCVP, etc. |
|
| Measure | Description | Time Frame |
|---|---|---|
| ORR | the ratio of numbers of patients with complete response and partial response to all the participants receiving treatment | up to 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| 2-year progression-free survival (PFS) | the period from the date of patients sign informed consent to the observed progression of the disease or the occurrence of death for any reason | From date of patients sign informed consent until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 2 years |
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Inclusion Criteria:
Exclusion Criteria:
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Eligibale patients who ≥ 18 years old, Initial or first recurrent iNHL, with no contraindications to any medication in the treatment plan are enrolled. They will sign an informed consent form. Pregnant or lactating women were excluded. And patients who may not benefit from receiving immunochemotherapy evaluated by researchers are also excluded.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Fudan University Shanghai Cancer Center | Shanghai | Shanghai Municipality | 200032 | China |
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| ID | Term |
|---|---|
| D008228 | Lymphoma, Non-Hodgkin |
| ID | Term |
|---|---|
| D008223 | Lymphoma |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D008232 | Lymphoproliferative Disorders |
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| 2-year event-free survival (EFS) | the period from the date of patients sign informed consent to the observed event for any reason | From date of patients sign informed consent until the date of first documented event, progression or date of death from any cause, whichever came first, assessed up to 2 years |
| overall survival | time between the date of patients sign informed consent and the date of death or the date of last follow-up time | From date of patients sign informed consent until the date of death or the date of last follow-up time, whichever came first, assessed up to 2 years |
| Hematology and non hematology toxicity | number of participants with treatment-related adverse events as assessed by CTCAE v5.0 | Throughout the treatment period,up to 6 months |
| D008206 |
| Lymphatic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D007160 | Immunoproliferative Disorders |
| D007154 | Immune System Diseases |