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| Name | Class |
|---|---|
| The University of Hong Kong | OTHER |
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Poor sleep quality can significantly jeopardize the brain health, cognitive functions, daily activities, quality of life, and even be implicated as a key potential contributing factor in the development of accelerated cognitive decline and prodromal dementia. Consequently, research efforts to understand, and therefore potentially model, the effects of sleep quality on cognition and brain health are of great pragmatic values.
Objectives: This study aims to investigate the cognitive changes in older adults with sleep disturbances, examine the neuroimaging contributors to poor sleep quality and cognitive deficits.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Poor sleepers | With a total score of Pittsburgh Sleep Quality Index (PSQI) > 5. | ||
| Good sleepers | With a total score of Pittsburgh Sleep Quality Index (PSQI) ≤ 5. |
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| Measure | Description | Time Frame |
|---|---|---|
| Sleep quality will be measured by the Pittsburgh Sleep Quality Index (PSQI) | Pittsburgh Sleep Quality Index (PSQI) is a validated 19-item self-reported questionnaire | Baseline |
| Global cognition will be measured by the Montreal Cognitive Assessment Hong Kong version (HK MoCA) | The Montreal Cognitive Assessment Hong Kong version (HK MoCA) is a validated and widely used screening assessment for detecting cognitive impairment, which measures an array of cognitive functions such as visuospatial, memory, language and attention. | Baseline |
| Complex attention will be measured by the Attention Network Test (ANT) | The ANT paradigm, as a computerized test, was used and performed by E-Prime 3.0. | Baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Memory and learning will be measured by the Word list learning test (WLLT) | Word list learning test (WLLT), consisting of fifteen semantically non-associated words that is presented consecutively over three free trials of immediate recall, a 20-min delayed recall and followed by yes/no recognition. | Baseline |
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Inclusion Criteria:
Exclusion Criteria:
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Healthy normal ageing adults and adults with sleep disturbances.
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| Name | Affiliation | Role |
|---|---|---|
| Hanna LU, PhD | Chinese University of Hong Kong | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The Chinese University of Hong Kong | Hong Kong | Tai Po District | 100000 | Hong Kong |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41882580 | Derived | Ni X, Yang NS, Yuen YS, Gong Y, Li Z, Hu X, Yuan Y, Lu H. HK-ASAP study: protocol for a prospective cohort study on sleep quality, brain reserve and cognitive phenotypes in community-dwelling older adults. BMC Geriatr. 2026 Mar 25;26(1):625. doi: 10.1186/s12877-026-07367-0. |
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| ID | Term |
|---|---|
| D020447 | Parasomnias |
| D060825 | Cognitive Dysfunction |
| D001927 | Brain Diseases |
| ID | Term |
|---|---|
| D012893 | Sleep Wake Disorders |
| D009422 | Nervous System Diseases |
| D001523 | Mental Disorders |
| D003072 | Cognition Disorders |
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Participant's saliva will be collected for further analysis.
| Executive functions will be measured by the category verbal fluency test (CVFT) |
On each trial of CVFT, the participants will be asked to overtly generate words in the animal category, fruit category and vegetable category as many as possible within 60 seconds |
| Baseline |
| The levels of Aβ40 and Aβ42 will be measured by saliva analysis | saliva samples will be collected at a consistent time of day to avoid circadian effects and will be kept on ice during the collection. | Baseline |
| D019965 |
| Neurocognitive Disorders |
| D002493 | Central Nervous System Diseases |