The purpose of this study is to find out how effective and safe glipizide is for lowering blood sugar in people with pancreatic cancer.

Inclusion Criteria:

Cohort 1

• Age ≥18 years
• Biopsy-proven PDAC
• Radiological evidence and clinical assessment that patient has active disease (local, locally advanced, or metastatic)
• Willing and able to comply with the requirements of the protocol
• Willing to use their bluetooth-enabled wifi or cellular mobile device
• Hemoglobin A1c (HbA1c) > 7%, or fructosamine > 287 mg/dL, or random glucose > 180 mg/dL, or strong clinical suspicion that patient has hyperglycemia, making it reasonable to expect their mean daily glucose is ≥154 mg/dL
• Eastern Cooperative Oncology Group performance status ≤2
• BMI <30 kg/m2

Cohort 2a

• Age ≥18 years
• Biopsy-proven PDAC
• Radiological evidence and clinical assessment that patient has active disease (local, locally advanced, or metastatic pancreatic cancer)
• Clinical diagnosis of diabetes mellitus
• Active care at MSK (defined as at least 1 physician or APP encounter every 3 months) for PDAC during the period from which data were recorded in the electronic medical record (in this retrospective study patients need not be under active care at the time the research is conducted)
• At least 1 electronic prescription for a sulfonylurea (glipizide, glimepiride, or glyburide) or metformin
• Three-month baseline period before metformin or sulfonylurea initiation in which the participant does not receive either drug class or insulin
• Body weight recorded within 3 months before start of metformin or a sulfonylurea

Cohort 2b

• Age ≥18 years
• Biopsy-proven PDAC
• Radiological evidence and clinical assessment that patient has active disease (local, locally advanced, or metastatic)
• Active care at MSK (defined as at least 1 physician or APP encounter every 3 months) for PDAC during the period of data collection
• Apparent current use based on chart review of metformin (but not sulfonylurea); sulfonylurea (but not metformin); or neither drug

Exclusion Criteria:

Cohort 1

• Use during the past month of any antidiabetic medication other than metformin at home (sporadic use [fewer than 1 of 7 days during the past month] is permitted)
• Changes in metformin dose in the past month
• History of sulfonylurea intolerance or allergy
• History of severe hypoglycemia (hypoglycemia requiring emergency medical assistance, emergency room or urgent care visit, or hospital admission)
• AST or ALT >3 x upper limit of normal
• Glomerular filtration rate <30 mL/min/1.73m2
• Daily chronic use of any dose of corticosteroids (as distinct from intermittent exposure to steroids as part of cyclic chemotherapy)
• Inability to wear CGM

Cohort 2a

• Greater than trace ascites documented on imaging or physical exam

Cohort 2b

• Greater than trace ascites documented on imaging or physical exam

Memorial Sloan Kettering Cancer Center supports the international committee of medical journal editors (ICMJE) and the ethical obligation of responsible sharing of data from clinical trials. The protocol summary, a statistical summary, and informed consent form will be made available on clinicaltrials.gov when required as a condition of Federal awards, other agreements supporting the research and/or as otherwise required. Requests for deidentified individual participant data can be made beginning 12 months after publication and for up to 36 months post publication. Deidentified individual participant data reported in the manuscript will be shared under the terms of a Data Use Agreement and may only be used for approved proposals. Requests may be made to: crdatashare@mskcc.org.

Requests for deidentified individual participant data can be made beginning 12 months after publication and for up to 36 months post publication.

The protocol summary, a statistical summary, and informed consent form will be made available on clinicaltrials.gov when required as a condition of Federal awards, other agreements supporting the research and/or as otherwise required.