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| Name | Class |
|---|---|
| University of Copenhagen | OTHER |
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To evaluate the influence of time of day on the circulating concentrations of various biochemical markers in healthy men
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| diurnal variations | Experimental | Venous blood samples were obtained under standardized conditions from 24 healthy young men every third hour through 24 hours |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Diurnal variation | Other | Venous blood samples were obtained under standardized circumstances from 24 healthy young men every third hour through 24 hours, nine time points in total. |
| Measure | Description | Time Frame |
|---|---|---|
| hematology parameters | Composite measurement of hematological measurements | 24 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Plasma Levels of Glucagon | 24 hours | |
| Plasma levels of GLP-1 | 24 hours | |
| Plasma levels of GIP |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Henriette P Sennels, MD PhD | Bispebjerg Hospital | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21988588 | Background | Sennels HP, Jorgensen HL, Hansen AL, Goetze JP, Fahrenkrug J. Diurnal variation of hematology parameters in healthy young males: the Bispebjerg study of diurnal variations. Scand J Clin Lab Invest. 2011 Nov;71(7):532-41. doi: 10.3109/00365513.2011.602422. | |
| 22282468 | Background | Goetze JP, Jorgensen HL, Sennels HP, Fahrenkrug J. Diurnal plasma concentrations of natriuretic propeptides in healthy young males. Clin Chem. 2012 Apr;58(4):789-92. doi: 10.1373/clinchem.2011.178921. Epub 2012 Jan 26. No abstract available. |
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| ID | Term |
|---|---|
| D002940 | Circadian Rhythm |
| ID | Term |
|---|---|
| D010507 | Periodicity |
| D002909 | Chronobiology Phenomena |
| D010829 | Physiological Phenomena |
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| 24 hours |
| Plasma levels of c-peptide | 24 hours |
| Plasma levels of glucose | 24 hours |
| 22397709 | Background | Sennels HP, Jorgensen HL, Goetze JP, Fahrenkrug J. Rhythmic 24-hour variations of frequently used clinical biochemical parameters in healthy young males--the Bispebjerg study of diurnal variations. Scand J Clin Lab Invest. 2012 Jul;72(4):287-95. doi: 10.3109/00365513.2012.662281. Epub 2012 Mar 8. |
| 24571735 | Background | Timm A, Fahrenkrug J, Jorgensen HL, Sennels HP, Goetze JP. Diurnal variation of von Willebrand factor in plasma: the Bispebjerg study of diurnal variations. Eur J Haematol. 2014 Jul;93(1):48-53. doi: 10.1111/ejh.12298. Epub 2014 Mar 18. |
| 26378655 | Background | Sennels HP, Jorgensen HL, Fahrenkrug J. Diurnal changes of biochemical metabolic markers in healthy young males - the Bispebjerg study of diurnal variations. Scand J Clin Lab Invest. 2015;75(8):686-92. doi: 10.3109/00365513.2015.1080385. Epub 2015 Sep 17. |
| 27494182 | Background | Heegaard NH, Carlsen AL, Lilje B, Ng KL, Ronne ME, Jorgensen HL, Sennels H, Fahrenkrug J. Diurnal Variations of Human Circulating Cell-Free Micro-RNA. PLoS One. 2016 Aug 5;11(8):e0160577. doi: 10.1371/journal.pone.0160577. eCollection 2016. |
| 31247945 | Background | Schroor MM, Sennels HP, Fahrenkrug J, Jorgensen HL, Plat J, Mensink RP. Diurnal Variation of Markers for Cholesterol Synthesis, Cholesterol Absorption, and Bile Acid Synthesis: A Systematic Review and the Bispebjerg Study of Diurnal Variations. Nutrients. 2019 Jun 26;11(7):1439. doi: 10.3390/nu11071439. |
| 32820681 | Background | Rehfeld JF, Sennels HP, Jorgensen HL, Fahrenkrug J. Circadian variations in plasma concentrations of cholecystokinin and gastrin in man. Scand J Clin Lab Invest. 2020 Nov;80(7):546-551. doi: 10.1080/00365513.2020.1804072. Epub 2020 Aug 21. |
| 42008634 | Derived | Albrethsen J, Andreasen JK, Anton J, Sennels HP, Jorgensen HL, Hannibal J, Hermann D, Wewer Albrechtsen NJ. Measurements of plasma melatonin by rapid LC-MS/MS enables insight into diurnal variation in healthy humans. Scand J Clin Lab Invest. 2026;86(3):306-312. doi: 10.1080/00365513.2026.2660758. Epub 2026 Apr 20. |
| 38481208 | Derived | Zilstorff DB, Richter MM, Hannibal J, Jorgensen HL, Sennels HP, Wewer Albrechtsen NJ. Secretion of glucagon, GLP-1 and GIP may be affected by circadian rhythm in healthy males. BMC Endocr Disord. 2024 Mar 14;24(1):38. doi: 10.1186/s12902-024-01566-9. |