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| Name | Class |
|---|---|
| Leibniz Research Centre for Working Environment and Human Factors | OTHER |
| Neuroelectrics Corporation | INDUSTRY |
| Zanjan University of Medical Sciences | OTHER |
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In this project, the efficacy of different tDCS protocols in major depression will be investigated. The tDCS protocols have already been investigated in humans, and results showed that stimulation intensity has a different effect on tDCS long-term aftereffects based on the human motor cortex model. The project has three major goals: first, we want to see if the differential outcome of tDCS dosage, as present in healthy populations, can be translated to patients with major depression. Second, we want to compare the efficacy of a multi-channel novel protocol with conventional tDCS modules. Lastly, we are interested in the safety and tolerability of optimized multi-channel. The project output will be an optimized tDCS protocol for major depression treatment.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| conventional tDCS group | Active Comparator | The conventional tDCS group will receive 30 sessions of 20-minute stimulation at 2 mA intensities using standard electrodes (7 x 5 cm) over the target region |
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| multi-channel tDCS group | Active Comparator | The multi-channel tDCS group will receive 30 sessions of 20-minute stimulation at 2 mA intensities using 7 electrodes (11 mm) over the target region |
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| sham tDCS group | Placebo Comparator | The conventional tDCS group will receive 30 session of 20-minute placebo stimulation using standard electrodes (7 x 5 cm) over the target region |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| transcranial direct current stimulation (tDCS) | Device | In tDCS, direct electrical currents at the intensity of interest (2 mA for example) are generated by an electrical stimulator and are noninvasively delivered to the scalp through a pair of saline-soaked sponge electrodes (7×5 cm) or via more than two but smaller round electrodes over the target regions. |
| Measure | Description | Time Frame |
|---|---|---|
| Montgomery-Asberg Depression Rating Scale scores | the score on the MADRS (Montgomery-Asberg Depression Rating Scale) | up to 3 months after the intervention |
| Hamilton Depression Rating Scale scores | the score on the Hamilton Depression Rating Scale (HDRS). The HDRS is a multiple-item questionnaire designed for measuring adult depression and is administered by health care professionals. It is currently the most common depression measure used worldwide. Items on the HDRS are scored from 0 to 4 or 0 to 2 depending on the symptom assessed, with high scores indicating greater symptom pathology. scores typically ranging from 15 to 20 indicate a clinical level of depressive symptomatology | up to 3 months after the intervention |
| Beck Depression Inventory scores | the score on the Beck Depression Inventory (BDI-II). The BDI is a self-reported twenty-one questions about how the subject has been feeling in the last week, and each question has four answers ranging in intensity. Scoring 19 or higher on the BDI-II is considered moderate depression | up to 3 months after the intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Working memory task | Performance in the Spatial Working Memory (SWM) task, which is a recommended test for depression by Cambridge Cognition (CANTAB) | up to 1 month after the intervention |
| Attention task |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Zanjan University of Medical Sciences | Zanjan | Zanjan Province | Iran |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41927768 | Derived | Salehinejad MA, Abdi M, Dadashi M, Habibi M, Hallajian AH, Sharifi K, Khadem A, Salvador R, Ruffini G, Nitsche MA. Optimized multichannel 4 mA vs conventional transcranial direct current stimulation for major depressive disorder: A randomized sham-controlled trial. Mol Psychiatry. 2026 Apr 2. doi: 10.1038/s41380-026-03560-0. Online ahead of print. |
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| ID | Term |
|---|---|
| D003866 | Depressive Disorder |
| D060825 | Cognitive Dysfunction |
| D001523 | Mental Disorders |
| D003865 | Depressive Disorder, Major |
| ID | Term |
|---|---|
| D019964 | Mood Disorders |
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
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| ID | Term |
|---|---|
| D065908 | Transcranial Direct Current Stimulation |
| ID | Term |
|---|---|
| D004599 | Electric Stimulation Therapy |
| D013812 | Therapeutics |
| D003295 | Convulsive Therapy |
| D013000 | Psychiatric Somatic Therapies |
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| RWTH Aachen University |
| OTHER |
randomized, double-blind, parallel group trial
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to secure investigator blinding, interventions were applied by independent investigators who were not involved in outcome measure ratings
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| multichannel transcranial direct current stimulation (tDCS) | Device | In multichannel tDCS, direct electrical currents at the intensity of interest (2 mA for example) are generated by an electrical stimulator and are noninvasively delivered to the scalp through more than two and smaller round electrodes over the target regions. |
|
Performance in the Rapid Visual Information Processing (RVP) task, which is a recommended test for depression by Cambridge Cognition (CANTAB)
| up to 1 month after the intervention |
| Emotion Recognition Task | Performance in the Emotion Recognition Task (ERT), which is a recommended test for depression by Cambridge Cognition (CANTAB) | up to 1 month after the intervention |
| electroencephalogram (EEG) functional connectivity | Change in the EEG functional connectivity in the frontal areas | up to 1 week after the intervention |
| electroencephalogram (EEG) power | Change in the EEG alpha/theta/gamma power | up to 1 week after the intervention |
| D004191 | Behavioral Disciplines and Activities |
| D004597 | Electroshock |
| D011580 | Psychological Techniques |