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| Name | Class |
|---|---|
| Hannover Medical School | OTHER |
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The study will analyze the auditory functions of patients with Multiple Sclerosis using auditory tests like pure tone auditory test, speech perception test, Auditory Brain Response (ABR) and Distortion Product Otoacustic Emission (DPOAE). CSF will be collected by lumbar puncture and analyzed looking for inflammatory markers.
The results of DPOAE and CSF will be correlated to identify statistically significant correlation.
Case-Control study
Tools for patients' selection and inclusion in the study
STEP one
STEP two
STEP three in case of Hearing impairment
- MRI Tractography
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | Healthy patients between 20 and 40 years |
| |
| MS group | Patient with Relapsing Remitting MS age between 20 and 40 years |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Auditory test | Diagnostic Test | The patients will perform: Pure Tone Auditory test + Tympanometry and Stapedial Reflex
|
| Measure | Description | Time Frame |
|---|---|---|
| Auditory functions and correlation with CSF findings | The worsening of the hearing thresholds and DPOAE results will be correlated with the presence of inflammatory elements in the CSF | 12 months |
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Inclusion Criteria
Exclusion Criteria
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Healthy patients and patients with RRMS
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Arianna Di Stadio | Recruiting | Catania | Sicily | 95121 | Italy |
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24 months for 12 months
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| ID | Term |
|---|---|
| D009103 | Multiple Sclerosis |
| D006311 | Hearing Disorders |
| ID | Term |
|---|---|
| D020278 | Demyelinating Autoimmune Diseases, CNS |
| D020274 | Autoimmune Diseases of the Nervous System |
| D009422 | Nervous System Diseases |
| D003711 | Demyelinating Diseases |
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| ID | Term |
|---|---|
| D001299 | Audiometry |
| ID | Term |
|---|---|
| D006320 | Hearing Tests |
| D003939 | Diagnostic Techniques, Otological |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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Cerebro-spinal-fluid
| CSF sampling | Other | Cerebrospinal Fluid will be collected by lumbar puncture and analyzed |
|
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |
| D004427 | Ear Diseases |
| D010038 | Otorhinolaryngologic Diseases |
| D012678 | Sensation Disorders |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |