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Calcium is an essential element for fundamental physiological functions and during pregnancy. However, higher calcium intake can induce constipation, flatulence, nausea, or kidney stones. This study aims to evaluate the incidence of hypocalcemia among pregnant women in the first half of pregnancy in Thailand. Also, Comparison of calcium level in pregnant women in the third trimester who received and not received calcium during pregnancy.
The primary outcome is the incidence of hypocalcemia among pregnant women in the first half of pregnancy. This study also has secondary objectives. The one is associating factors with calcium level. After getting the results of maternal calcium level, the normal calcium level group will be divided into 2 groups for receiving calcium 1 g/day and no receiving calcium supplement. Another with hypocalcemia group will be decided into 2 groups for receiving calcium 1 g/day and 2 g/day. The calcium level was collected again in the third trimester.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Normal calcium level with no receiving calcium supplement | No Intervention | Pregnant women with normal calcium level in the first half of pregnancy do not receive calcium supplement. | |
| Normal calcium level with receiving calcium supplement 1g/day | Experimental | Pregnant women with normal calcium level in the first half of pregnancy receive calcium supplement 1g/day. |
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| Hypocalcemia with receiving calcium supplement 1g/day | Experimental | Pregnant women with hypocalcemia in the first half of pregnancy receive calcium supplement 1g/day. |
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| Hypocalcemia level with receiving calcium supplement 2g/day | Experimental | Pregnant women with hypocalcemia in the first half of pregnancy receive calcium supplement 2g/day. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Calcium supplement | Drug | Different amount of calcium supplement in pregnancy |
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| Measure | Description | Time Frame |
|---|---|---|
| The incidence of hypocalcemia in pregnant women at Siriraj Hospital | The incidence of hypocalcemia in pregnant women in the first half of pregnancy. Material blood will be taken for calcium level. The hypocalcemia is defined as total calcium level less than 8.5 mg/dl. | 1.5 year |
| Measure | Description | Time Frame |
|---|---|---|
| The demographic and pregnant factors are associating with maternal calcium level in the first half of pregnancy assessed by the questionnaire and scrupulous chart review | The different characteristics between normal calcium and hypocalcemia group in the first half of pregnancy will be studied. The data will be received by interviewing the patients, answering the questionnaire and scrupulous chart review; including age, education, occupations, income, marital status, food and nutrition status, previous pregnancy outcomes, family history, mode of conception in this pregnancy, gestational age of blood drawing, caffeine intake, smoking, and maternal hematocrit. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Tachjaree Panchalee, MD | Siriraj Hospital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of Medicine Siriraj Hospital | Bangkoknoi | Bangkok | 10700 | Thailand |
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| 1.5 year |
| The calcium level in pregnant women in the third trimester | Comparison of maternal serum calcium level in pregnant women in the third trimester between who receive and do not receive calcium supplement. In the normal calcium level group, pregnant women will be divided into 2 groups: receiving CaCO3 1 g/day and no receiving. In the hypocalcemia group, pregnant women will be divided into 2 groups: receiving CaCO3 1g/day and 2g/day. Maternal blood taking for serum calcium level will be done in all participants. Comparison of maternal calcium level between groups will be reported. Statistical analysis will be used t-test and p-value is less than 0.5. | 2 year |