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The goal of this clinical trial is to compare the expression of multiple genes related to bone regeneration in maxillary bone after being grafted with a commonly used biomaterial supplemented or not with a combination of hyaluronic acid and polynucleotides.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Anorganic bovine bone | Active Comparator | Maxillary sinus floor augmentation grafted with anorganic bovine bone |
|
| Anorganic bovine bone + polynucleotides and hyaluronic acid | Experimental | Maxillary sinus floor augmentation grafted with anorganic bovine bone + polynucleotides and hyaluronic acid |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Maxillary sinus floor augmentation | Procedure | Maxillary sinus floor augmentation through a lateral window grafted with anorganic bovine bone + polynucleotides and hyaluronic acid |
| Measure | Description | Time Frame |
|---|---|---|
| Transcriptome analysis | Transcriptome analysis of a sample of the regenerated bone will be performed 6 months after grafting immediately before implant placement | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Sinus floor height change | CBCT scans will be performed after the sinus floor elevation and 6 months later before implant placement to calculate vertical bone height change | 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Universidad de Granada | Granada | Granada | 18009 | Spain |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35224778 | Background | Galindo-Moreno P, Abril-Garcia D, Carrillo-Galvez AB, Zurita F, Martin-Morales N, O'Valle F, Padial-Molina M. Maxillary sinus floor augmentation comparing bovine versus porcine bone xenografts mixed with autogenous bone graft. A split-mouth randomized controlled trial. Clin Oral Implants Res. 2022 May;33(5):524-536. doi: 10.1111/clr.13912. Epub 2022 Mar 3. | |
| 29071736 |
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| Maxillary sinus floor augmentation | Procedure | Maxillary sinus floor augmentation through a lateral window grafted with anorganic bovine bone |
|
| Galindo-Moreno P, de Buitrago JG, Padial-Molina M, Fernandez-Barbero JE, Ata-Ali J, O Valle F. Histopathological comparison of healing after maxillary sinus augmentation using xenograft mixed with autogenous bone versus allograft mixed with autogenous bone. Clin Oral Implants Res. 2018 Feb;29(2):192-201. doi: 10.1111/clr.13098. Epub 2017 Oct 26. |
| ID | Term |
|---|---|
| D059546 | Sinus Floor Augmentation |
| ID | Term |
|---|---|
| D019647 | Oral Surgical Procedures |
| D013514 | Surgical Procedures, Operative |
| D016025 | Bone Transplantation |
| D019637 | Orthopedic Procedures |
| D003813 | Dentistry |
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