This clinical trial aims to compare the effectiveness of Robotic versus conventional mirror therapy among post-stroke patients. The main questions it aims to answer are:

• Effectiveness of both interventions in hand motoric recovery across time
• Effectiveness of both interventions in functional outcomes across time
• Clinical outcome difference between both interventions Participants will be allocated into either a robotic group as the main intervention or a mirror therapy group as the active comparator. A serial follow-up will be conducted to assess the selected clinical outcome and differences in outcome

1. Research design This research is an experimental study with a randomized controlled trial research design.

2. Study Setting The research will be carried out among post-stroke patients at two teaching hospitals and one physical rehabilitation centre in Makassar

3. Procedure

   1. Robotic Procedure an exoskeletal robot (Syrebo) will help and stimulate the movement of the paralyzed extremity. One set of training covering Activity Daily Living (ADL) set will be conducted. A mirror will reflect the movement of the healthy extremities
   2. Conventional Method the difference from the robotic procedure was, the movement and stimulation will be provided by the physical therapist.

4. Time frame the procedure will be conducted in parallel three times per week for a total of six weeks

5. Outcomes

   1. motoric ability of upper extremity using Fugl-Meyer Assessment for Upper Extremities (FMA-UE)
   2. Dexterity, coordination and response of finger using the Nine Hole Peg Test (NHPT)

6. Covariates and potential confounders

   1. type of stroke determined by radiology imaging
   2. phase of stroke (acute, sub-acute or chronic)
   3. cognitive ability measured using mini-mental state examination (MMSE)
   4. Spasticity measured by the Modified Ashworth Scale (MAS)

7. Procedure The data collected is primary data obtained in accordance with the inclusion criteria.

   Samples who are willing to become research subjects will undergo interviews, physical examinations, FMA-UE-Hand Motor Domain and NHPT examinations. The interview questionnaire in this study will contain a list of patient identities including name, age, marital status, address, educational history, employment history, history of stroke, cognitive examination (MMSE), and self-reported visual ability.

   The FMA-UE-Hand Motor Domain scoring system is used to evaluate upper extremity motor function in patients with neurological disorders, such as stroke. The scoring system ranges from 0-14, with higher scores indicating better motor function. The FMA-UE-Hand Motor domain assessment system is broken down into several subscales, namely Mass Flexion and Extension movements, followed by functional movements of grasping (Grasp), including Hook Grasp, Thumb Adduction, Pincer Grasp, Cylinder Grasp, and Spherical Grasp. The assessment will get a score of 0 = None or no movement, 1 = Partial or limited movement, and 2 = Full or perfect movement.

   The NHPT assessment consists of a square board with 9 pegs. At one end of the board, there is a hole for the peg, and at the other end, there is a shallow round plate for holding the peg. NHPT is performed by having the patient take pegs from a container, one at a time, and place them into the holes in a board, as quickly as possible. The patient must then remove the pegs from the holes, one at a time, and reinsert them into the housing. To practice and register initial scores, the test must be started with the unaffected upper limb. The board should be placed in the centre of the patient's body with the housing holding the pegs oriented toward the hand being tested. Only the hand being evaluated should perform the test. The non-evaluated hand is allowed to grip the edge of the board to provide stability. Patients are scored based on the time required to complete the test activity, recorded in seconds. The stopwatch must start from the moment the participant touches the first peg until the last peg touches the container. This assessment requires a board, of wood or plastic, with 9 holes (10 mm diameter, 15 mm depth), spaced 32 mm or 50 mm apart and a stopwatch.

8. Sample Size Based on previous research, the value of the standard deviation of the selected outcome = 11.5 and the value of x1-x2 = 9.1 (Lin, 2020). The Zα value = 1.96 with a confidence interval of 95% and the Zβ value = 0.84 with a power of 80%, two arms and a dropout rate of 30% at least 40 participants should be recruited. A consecutive sampling will be applied and allocated randomly using the simple randomization technique.

9. Proposed Statistical Analysis Data on the effect of robotic mirror therapy compared to conventional mirror therapy will be assessed using the independent t-test. Data from the FMA-UE and NHPT assessments before and after the intervention will be analyzed using the paired t-test. Next, the relationship between the FMA-UE and NHPT values will be assessed using the Pearson correlation test (normally distributed data) or the Spearman test (data not normally distributed) to determine how big the correlation is between these variables.

Inclusion criteria:

1. Patients aged 20 - 85 years.
2. Non-haemorrhagic stroke/infarction with onset more than 3 months from the onset of the attack.
3. Patients with unilateral upper limb hemiparesis.
4. Modified Ashworth Scale (MAS) on fingers and hands <3
5. The patient has not undergone mirror therapy treatment before.
6. Patients who are able to understand informed consent to participate in research.
7. The patient had a Radiology imaging of the head at the time of stroke onset.

Exclusion criteria:

1. Patients with severe spasticity or contractures of the upper extremities.
2. Patients with infarction/bleeding with extensive lesions covering 2 hemispheres.
3. The patient has severe cognitive impairment that will interfere with the research objectives (MMSE score >24).
4. Patients post Digital Subtraction Angiography (DSA) procedures in the last 2 months.
5. Patients with a history of seizures or epilepsy.
6. Patients with visual field deficits or severe visual impairment.
7. Patients who are unable to sit upright without assistance.
8. Other uncontrolled medical conditions (musculoskeletal, neuromuscular, cardiorespiratory) that may interfere with the ability to exercise.

Dropout criteria:

Patients were excluded from the study if:

1. Participant dies.
2. Participants take part in the exercise <3 times for 2 consecutive weeks.
3. The participant refuses to continue the training session.
4. Participants experience hemodynamic disorders during the training program phase.
5. Participants experience neurological disorders during the training program phase.

To protect the confidentiality, should the data need to share, any de-identified data will be shared for peer-review