INtensity of OVarian Stimualtion and Euploid Embryos

The Impact of Ovarian Stimulation Intensity on Embryo Euploidy in Advanced Age Women

This randomized trial was designed as a no-inferiority trial aiming to evaluate if the intensity of stimulation (a milder vs a more intense approach) may have an impact on the number of euploid embryos and the morpho kinetic parameters in advanced age women undergoing PGT-A with a PPOS protocol.

Inclusion Criteria:

• Infertile patients with indication for IVF
• Undergoing preimplantation genetic screening cycles
• AMH >= 1.5 ng/ml and < 3.5 ng/ml (AMH result of up to one year will be valid)
• BMI 18.5 - 30 Kg/m2

Exclusion Criteria:

• Severe male factor requiring TESE (testicular sperm extraction)
• AMH < 1.5 ng/ml or >= 3.5 ng/ml
• Administration of any other drug potentially interfering with the treatment
• Contraindication for hormonal treatment
• Recent history of severe disease requiring regular treatment (clinically significant concurrent medical condition that could compromise subject safety or interfered with the trial assessment).
• Monogenic disease to be detected with PGT-M