A PHASE 3, OPEN-LABEL STUDY OF ELRANATAMAB MONOTHERAPY VERSUS ELOTUZUMAB, POMALIDOMIDE, DEXAMETHASONE (EPd) OR POMALIDOMIDE, BORTEZOMIB, DEXAMETHASONE (PVd) OR CARFILZOMIB, DEXAMETHASONE (Kd) IN PARTICIPANTS WITH RELAPSED/REFRACTORY MULTIPLE MYELOMA WHO RECEIVED PRIOR ANTI-CD38 DIRECTED THERAPY
A PHASE 3, OPEN-LABEL STUDY OF ELRANATAMAB MONOTHERAPY VERSUS ELOTUZUMAB, POMALIDOMIDE, DEXAMETHASONE (EPd) OR POMALIDOMIDE, BORTEZOMIB, DEXAMETHASONE (PVd) OR CARFILZOMIB, DEXAMETHASONE (Kd) IN PARTICIPANTS WITH RELAPSED/REFRACTORY MULTIPLE MYELOMA WHO RECEIVED PRIOR ANTI-CD38 DIRECTED THERAPY
The purpose of this study is to learn about the study medicine called elranatamab.This study aims to compare elranatamab to other medicines for the treatment of MM (a type of cancer).
This study is seeking participants who:
Half of the participants will receive elranatamab. The other half of participants will receive a combination therapy selected by the study doctor. The selected combination therapy will include 2 to 3 different medicines commonly used to treat MM.
Elranatamab will be given as a shot under the skin at the study clinic about once a week. This may change to a smaller number of shots later in the study.
The medicines in the combination therapy will be taken by mouth (at home or at the study clinic) AND will be given either as:
Participants may continue to receive elranatamab or a combination therapy until their MM is no longer responding. The study team will see how each participant is doing with the study treatment during regular visits at the study clinic. The study team will continue to follow-up with participants after study treatment with telephone contacts (or visits).
The study will compare the experiences of people receiving elranatamab to those people receiving a combination therapy. This will help learn about the safety and how effective elranatamab is.
Inclusion Criteria:
Exclusion Criteria:
ClinicalTrials.gov_Inquiries@pfizer.com1-800-718-1021
Goodyear, Arizona 85338, United States
Encino, California 91316, United States
Los Angeles, California 90020, United States
Los Angeles, California 90048, United States
Newport Beach, California 92663, United States
Sacramento, California 95817, United States
Coral Gables, Florida 33146, United States
Deerfield Beach, Florida 33442, United States
Miami, Florida 33136, United States
Glenview, Illinois 60026, United States
Highland Park, Illinois 60035, United States
Zion, Illinois 60099, United States
Kansas City, Kansas 66112, United States
Merriam, Kansas 66204, United States
Belton, Missouri 64012, United States
Kansas City, Missouri 64132, United States
Morristown, New Jersey 07960, United States
Cincinnati, Ohio 45242, United States
Nashville, Tennessee 37203, United States
Nashville, Tennessee 37203, United States
Nashville, Tennessee 37203, United States
Nashville, Tennessee 37203, United States
Dallas, Texas 75246, United States
Madison, Wisconsin 53718, United States
Madison, Wisconsin 53792, United States
Ciudad Autónoma de Buenos Aires, Buenos Aires C1426ANZ, Argentina
Ciudad de Buenos Aires, Buenos Aires F.D. C1199ABB, Argentina
Nedlands, Western Australia 6009, Australia
Yvoir, Namur 5530, Belgium
Salvador, Estado de Bahia 41253-190, Brazil
Porto Alegre, Rio Grande do Sul 90110-270, Brazil
Porto Alegre, Rio Grande do Sul 90850-170, Brazil
Ribeirão Preto, São Paulo 14051-140, Brazil
SP, São Paulo 04537-080, Brazil
São Paulo, 01232-010, Brazil
Copenhagen Ø, DK 2100, Denmark
Helsinki, Uusimaa 00029, Finland
Toulouse, Haute-garonne 31100, France
Nantes, Pays de la Loire Region 44000, France
City/Town/Village, Vienne 86021, France
Tours, 37044, France
Alexandroupoli, Anatolikí Makedonía KAI Thráki 681 00, Greece
Thessaloniki, Kentrikí Makedonía 54639, Greece
Ramat Gan, Central District 5265601, Israel
Turin, Piedmont 10126, Italy
Bologna, 40138, Italy
Meldola (FC), 47014, Italy
Shiwa-gun Yahaba-cho, Iwate 028-3695, Japan
Bunkyo-ku, Tokyo 113-8603, Japan
Koto, Tokyo 135-8550, Japan
Koto, Tokyo 135-8550, Japan
Dordrecht, South Holland 3318 AT, Netherlands
Lørenskog, Akershus 1478, Norway
Lisbon, Lisbon District 1099-023, Portugal
Banská Bystrica, Banská Bystrica Region 97517, Slovakia
Košice, Košice Region 040 11, Slovakia
Bratislava, 851 07, Slovakia
Seoul, Seoul-teukbyeolsi [seoul] 03722, South Korea
Badalona, Barcelona [barcelona] 08916, Spain
Terrassa, Barcelona [barcelona] 08221, Spain
Barakaldo, Basque Country 48903, Spain
Murcia, Galicia [galicia] 30008, Spain
Girona, Girona [gerona] 17007, Spain
Salamanca, 37007, Spain
Bodelwyddan, Denbighshire [SIR Ddinbych Gb-ddb] LL18 5UJ, United Kingdom