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. To determine pattern and frequency of dyslipoproteinemia in patients with newly diagnosed juvenile SLE and to assess effect of disease activity on lipid profile of patients with juvenile SLE.
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by multisystem inflammation and the presence of circulating autoantibodies against self-antigens leading to inflammatory damage of many target organs including the skin, joints, kidneys, blood cells, blood vessels, and the central nervous system.Premature atherosclerosis has been recognized as an important issue for patients with SLE since the mid-1970s. Among the traditional risk factors of atherosclerosis, a history of smoking, diabetes, hypertension, and abnormal lipid profile have been shown to be important (7). In patients with juvenile SLE, smoking, diabetes, and uncontrolled hypertension are not common and therefore abnormal lipid profiles may be the most important risk factor.The lipid profile of both children and adults with SLE is the result of a combination of the influences of active disease, therapies, and genetics. The best way to determine the maximal potential effect of disease activity itself would be to examine patients at the time of presentation of SLE, when they are likely to have high disease activity but no effect of corticosteroid therapy.Studies in patients with active SLE suggested that there is a distinct pattern of lipid abnormalities of increased very low-density lipoprotein (VLDL) and triglycerides and decreased high-density lipoprotein (HDL-C), cholesterol and apolipoprotein A1 levels ("active SLE pattern")
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| newly diagnosed juvenile systemic lupus erythematosus |
| ||
| old cases of juvenile systemic lupus in activity |
| ||
| old cases of juvenile systemic lupus not in activity(controlled) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| lipid profile | Other | Measurements for CHOL,TG,LDL-C and HDL-C obtained following an overnight fasting |
|
| Measure | Description | Time Frame |
|---|---|---|
| lipid profile | pattern and frequency of dyslipoproteinemia in patients with newly diagnosed JSLE . | 2 years |
| lipid profile | effect of disease activity on lipid profile of patients with JSLE | 2 years |
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Inclusion Criteria:
Exclusion Criteria:
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.Patients diagnosed with jSLE between 5 and 18 years of age
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Sara A Mahmoud, resident | Contact | +02-01144250777 | saraabdelnassermahmoud1997@gmail.com | |
| Jaafar I Mohamad, professor | Contact | +02-01020627864 | Gafaribrahim2015@aun.edu.eg |
| Name | Affiliation | Role |
|---|---|---|
| Jaafar I Mohamad, professor | Assiut University | Principal Investigator |
| Naglaa S Mohamad, lecturer | Assiut University | Principal Investigator |
| Yosra M Mamdouh, lecturer |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Assiut university | Recruiting | Asyut | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 17265498 | Background | Sarkissian T, Beyene J, Feldman B, McCrindle B, Silverman ED. Longitudinal examination of lipid profiles in pediatric systemic lupus erythematosus. Arthritis Rheum. 2007 Feb;56(2):631-8. doi: 10.1002/art.22332. | |
| 17787042 | Background | Tyrrell PN, Beyene J, Benseler SM, Sarkissian T, Silverman ED. Predictors of lipid abnormalities in children with new-onset systemic lupus erythematosus. J Rheumatol. 2007 Oct;34(10):2112-9. Epub 2007 Sep 1. |
| Label | URL |
|---|---|
| Related Info | View source |
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| ID | Term |
|---|---|
| D008180 | Lupus Erythematosus, Systemic |
| ID | Term |
|---|---|
| D003240 | Connective Tissue Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |
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| Assiut University |
| Principal Investigator |
| 26573664 | Background | Machado D, Sarni RO, Abad TT, Silva SG, Khazaal EJ, Hix S, Correia MS, Suano-Souza FI, Len CA, Terreri MT. Lipid profile among girls with systemic lupus erythematosus. Rheumatol Int. 2017 Jan;37(1):43-48. doi: 10.1007/s00296-015-3393-z. Epub 2015 Nov 16. |
| 32935804 | Background | Rodrigues WDR, Sarni ROS, Abad TTO, Silva SGLD, Souza FIS, Len CA, Terreri MT. Lipid profile of pediatric patients with chronic rheumatic diseases - a retrospective analysis. Rev Assoc Med Bras (1992). 2020 Aug;66(8):1093-1099. doi: 10.1590/1806-9282.66.8.1093. |