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The study aims to compare the effect of two different classes of anti- diabetes medications on prostate volume and symptoms in elderly patients with diabetes mellitus
The study aims to compare the effect of two different classes of anti- diabetes medications on prostate volume and symptoms in elderly patients with diabetes mellitus The study compares sodium glucose cotransporter 2 inhibitors to Dipeptidyl peptidase 4 inhibitors in elderly patients with type 2 diabetes mellitus
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Sodium glucose cotransporter 2 inhibitors | Active Comparator | patients with diabetes treated with sodium glucose cotransporter 2- Dapagliflozin |
|
| Dipeptidyl peptidase 4 inhibitors | Active Comparator | patients with diabetes treated with Dipeptidyl peptidase 4 inhibitor-sitagliptin |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| International prostate symptom score | Other | Questionnaire of 8 questions to be administered to all patients about prostate symptoms |
|
| Measure | Description | Time Frame |
|---|---|---|
| change in prostate volume | The delta change in prostate volume as measured by Ultrasound | one year |
| Change in prostate symptoms | As indicated by change in the International prostate score system | one year |
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Inclusion Criteria:
Exclusion Criteria:
Male patients with benign prostatic hyperplasia
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| Name | Affiliation | Role |
|---|---|---|
| Tarek Abdelaziz | Cairo University Kasr Alainy Faculty of Medicine | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cairo university hospitals | Cairo | Egypt | ||||
| Kasr Alainy University Hospitals |
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| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D011470 | Prostatic Hyperplasia |
| ID | Term |
|---|---|
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
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| Assessment of prostate volume | Diagnostic Test | Measurements using ultrasound |
|
| Pittsburgh sleep quality Index | Other | Questionnaire to assess quality of sleep |
|
| Glycated hemoglobin | Diagnostic Test | Measures control of diabetes |
|
| Cairo |
| Egypt |
| D011469 | Prostatic Diseases |
| D005832 | Genital Diseases, Male |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |