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| Name | Class |
|---|---|
| Ain Shams University | OTHER |
| Misr University for Science and Technology | OTHER |
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The aim of this study is to evaluate the effect of smoking cessation on inflammatory markers following non-surgical treatment of periodontal disease. This is to assess the period of smoking abstinence needed before any periodontal surgery in order to reverse the negative effects of the reported increased levels of inflammatory markers (IL-1β and PGE2 in this study) associated with smoking on the healing and the periodontium.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Previous smokers - Minimally invasive | Active Comparator | Minimally invasive non-surgical periodontal treatment |
|
| Previous smokers - Conventional | Active Comparator | Conventional non-surgical periodontal treatment |
|
| Smoker | Active Comparator | Conventional non-surgical periodontal treatment |
|
| Non-smoker | Active Comparator | Conventional non-surgical periodontal treatment |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Minimally invasive non-surgical periodontal therapy | Procedure | Minimally invasive non-surgical periodontal therapy |
|
| Measure | Description | Time Frame |
|---|---|---|
| Levels of Prostaglandin E2 | Salivary biochemical analysis | Baseline and 2 months |
| Interleukin 1 beta (in PG/ml) | Salivary biochemical analysis | Baseline and 2 months |
| Measure | Description | Time Frame |
|---|---|---|
| Pocket depth (in mm) | Periodontal clinical parameter | Baseline and 9 months |
| clinical attachment level (in mm) | Periodontal clinical parameter |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Noura M ElShiaty, Dr. | Master Degree in Diagnosis, Oral Medicine and Periodontology - Faculty of Dentistry - Ain Shams University, Membership of the Faculty of Dental Surgery of The Royal College of Surgeons of Edinburgh | Principal Investigator |
| Fatma H El-Demerdash, Associate Professor | Associate Professor of Periodontology, Oral Medicine and Diagnosis - Faculty of Dentistry - Ain Shams University, Associate Professor of Oral Medicine and Periodontology - Faculty of Oral and Dental Medicine - Misr International University | Study Director |
| Hussien Elkholy, Associate Professor | Associate Professor of Psychiatry - Faculty of Medicine - Ain Shams University | Study Director |
| Ahmed Y Gamal, Professor | Professor of Oral Medicine, Periodontology and Oral Diagnosis - Faculty of Dentistry - Ain Shams University, Professor of Periodontology - College of Oral and Dental Surgery - Misr University for Science and Technology | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ain Shams University | Cairo | 11566 | Egypt |
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| Conventional non-surgical periodontal therapy | Procedure | Conventional non-surgical periodontal therapy |
|
| Baseline and 9 months |
| bone gain (in mm) | Periodontal clinical parameter | Baseline and 9 months |
| Plaque index (scores) | Periodontal clinical parameters | Baseline and 9 months |
| Periodontal clinical parameters | Gingival index (scores) | Baseline and 9 months |
| ID | Term |
|---|---|
| D010510 | Periodontal Diseases |
| D016540 | Smoking Cessation |
| D012907 | Smoking |
| ID | Term |
|---|---|
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
| D015438 | Health Behavior |
| D001519 | Behavior |
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