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This study aims to test whether aerobic exercise performed after fear extinction learning improves cognitive, physiological, and neural indices of extinction recall in a sample of trauma-exposed men and women with and without posttraumatic stress disorder (PTSD). Participants will complete a clinical intake visit (Day 0), followed by a three-day fear conditioning (day 1), fear extinction + activity (day 2), and fear extinction recall (day 3) protocol.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Light-intensity aerobic exercise | Experimental |
| |
| Moderate-intensity aerobic exercise | Experimental |
| |
| High-intensity aerobic exercise | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Exercise | Behavioral | Participants will complete either a 30-minute bout of light-, moderate-, or high-intensity aerobic exercise at one of the visits. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Skin conductance responses | SCR data will be collected while participants are completing the cognitive task in the MRI environment. | Collected during fear conditioning, fear extinction, and extinction recall task. |
| Threat expectancy ratings | Threat expectancy ratings will be collected while participants are completing the cognitive task in the MRI environment. | Collected during fear conditioning, fear extinction, and extinction recall task. |
| Neural activity | Neural activity will be collected while participants are completing the cognitive task in the MRI environment. | Collected during fear conditioning, fear extinction, and extinction recall task. |
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Inclusion Criteria for PTSD:
Inclusion criteria for the trauma-exposed (without PTSD) control participants includes:
Exclusion Criteria for all participants:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Kevin Crombie, PhD | Contact | 2053482684 | kmcrombie@ua.edu |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Wade Hall - University of Alabama | Recruiting | Tuscaloosa | Alabama | 35487 | United States |
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| ID | Term |
|---|---|
| D013313 | Stress Disorders, Post-Traumatic |
| ID | Term |
|---|---|
| D040921 | Stress Disorders, Traumatic |
| D000068099 | Trauma and Stressor Related Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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