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Patients presenting with mild symptoms of acute ischemic stroke are common and account for approximately half of all acute ischemic stroke. About 30% of patients with minor stroke have a 90-day functional disability. Radiologically proven a large vessel occlusion (LVO) in patients with minor stroke is a well-established predictor of poor outcomes, while the poor outcomes following best medical management in patients with minor stroke with the underlying presence of a LVO are mainly driven by the occurrence of early neurological deterioration (END).
Considering the well-known strong association between lack of arterial recanalization and END, endovascular therapy (EVT) appears as an attractive option to improve functional outcomes for LVO-related patients with stroke with mild symptoms. Whether EVT is safe and effective in patients with mild stroke with an LVO is currently debated, since these patients were typically excluded from the pivotal EVT trials.
The current study aimed to further test the hypothesis that endovascular therapy would be superior to medical management with respect to functional recovery among low NIHSS patients caused by acute large-vessel occlusion in the anterior circulation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| EVT group | Experimental | In the procedure, the methods including mechanical thrombectomy, aspiration thrombectomy, intra-arterial thrombolysis, angioplasty and stenting can be used according to the local interventionalists' choice. |
|
| Best medical management | Active Comparator | All the patients enrolled received standard guideline-directed medical therapy including: monitor vital signs, management of blood pressure, glucose and lipids, antithrombotic (antiplatelet or anticoagulant therapy determined by treating physician) therapy if appropriate. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Endovascular therapy | Procedure | Drug: Best medical management All the patients enrolled received standard guideline-directed medical therapy including: monitor vital signs, management of blood pressure, glucose and lipids, antithrombotic (antiplatelet or anticoagulant therapy determined by treating physician) therapy if appropriate. Procedure: Endovascular therapy In the procedure, the methods including mechanical thrombectomy, aspiration thrombectomy, intra-arterial thrombolysis, angioplasty and stenting can be used according to the local interventionalists' choice. Mechanical thrombectomy or aspiration thrombectomy will be recommended as the primary treatment. |
| Measure | Description | Time Frame |
|---|---|---|
| 90-day excellent clinical outcome | a dichotomized mRS 0-1 outcome | 90±7 days after randomization |
| Measure | Description | Time Frame |
|---|---|---|
| Good clinical outcome | defined as a dichotomized mRS 0-2 | 90±7 days after randomization |
| early recovery | 72-hour NIHSS score≥4 points drop as compared with baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Rate of symptomatic intracranial hemorrhage (sICH) per Heidelberg standard | Heidelberg standard was defined as new intracranial hemorrhage detected by brain imaging associated with any of the item below: 4 points total NIHSS at the time of diagnosis compared to immediately before worsening. 2 point in one NIHSS category. Leading to intubation/hemicraniectomy/ventricular drainage placement or other major medical/surgical intervention. Absence of alternative explanation for deterioration. |
Aged 18 years or older;
The time from onset of acute ischemic stroke to arterial puncture is within 24 hours. Onset time is defined as the patient's Last Known Well (LKW);
Low NIHSS score (2-5 points), with at least one of the following items:
Intracranial internal carotid artery, proximal M1 or M2 segment of middle cerebral artery occlusion (excluding tandem lesions) confirmed by cerebral CTA/MRA/DSA before randomization, which is identified as the culprit vessel for stroke;
All patients receive CTP/MR perfusion imaging, with a volume of perfusion delay (Tmax>6 s) ≥ 50 mL;
Written informed consent is obtained from the patient or legal surrogate, with agreement for long-term follow-up.
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Zhiming Zhou, PhD | Contact | (++)86-(+)-553-5739543 | neuro_depar@hotmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The First Affiliated Hospital, Yijishan Hospital of Wannan Medical College | Recruiting | Wuhu | Anhui | 241000 | China |
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Drug: Best medical management Procedure: Endovascular therapy
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|
| Best medical management | Drug | All the patients enrolled received standard guideline-directed medical therapy including: monitor vital signs, management of blood pressure, glucose and lipids, antithrombotic (antiplatelet or anticoagulant therapy determined by treating physician) therapy if appropriate. |
|
| 72 hours after randomization |
| within 72 hours after randomization |
| All-cause mortality rate | All-cause mortality rate | 90±7 days after randomization |
| ID | Term |
|---|---|
| D000083242 | Ischemic Stroke |
| D019965 | Neurocognitive Disorders |
| ID | Term |
|---|---|
| D020521 | Stroke |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D001523 | Mental Disorders |
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