The project aims to identify the possible risk factors regarding the onset of the disease and to evaluate genes and gene modifications responsible for the onset od testicular cancer.

Testicular tumor represents a relatively rare disease that hit young-adults men. It represents 1% of all male cancers and 5% of all urological male tumors. Its incidence grow year by year. In the field of the oncological research, the lack of knowledge about genes related to this disease represent a very relevant clinical question. For this reason this project aims to collect biological samples of saliva from testicular cancer patients and from their first-degree family members; demographic-clinical variables will be also collected in order to draft a comprehensive panel of genes and gene modifications related to the testicular cancer, combining this survey with a very detailed description of this cohort of patient in terms of clinical features and quality of life.

Inclusion Criteria:

• Male testicular cancer patients with an age > 18 and < 90
• First degree family members of Male testicular cancer patients with an age > 18 and < 90
• Ability to read and sign the informed consent
• Diagnosis of testicular cancer for the experimental group

Exclusion Criteria:

• Female for the experimental group
• Second degree family members of Male testicular cancer patients
• People with an age < 18 and > 90
• Diagnosis different from testicular cancer for the experimental group Incapacity to read and sign the informed consent