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| Name | Class |
|---|---|
| 521 Hospital of NORINCO Group | OTHER |
| Shaanxi Provincial People's Hospital | OTHER |
| Xiangyang Central Hospital | OTHER |
| Henan Provincial People's Hospital |
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This study aims to analyze changes in the immune status, metabolic status, and host microbiome community structure in non-valvular atrial fibrillation patients with intracardiac thrombus. Additionally, the study aims to analyze factors that influence the responsiveness and occurrence of adverse events related to anticoagulant therapy.
The researcher-initiated clinical cohort study is a national multicenter, retrospective-prospective study of non-valvular atrial fibrillation patients with intracardiac thrombus, based on molecular biology and multi-omics analysis. The study aims to analyze the changes in the body's immune status, metabolic status, and host microbiome community structure, as well as to analyze the factors that influence the responsiveness of intracardiac thrombus to anticoagulant therapy. The study also evaluates the occurrence of adverse events related to anticoagulation in these patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Experimental group | Adequate and regular anticoagulant therapy. Anticoagulation therapy is determined based on the patient's CHADS₂ or CHA₂DS₂-VASc score. Anticoagulant medications include vitamin K antagonists, novel oral anticoagulants (NOACs), and aspirin. |
| |
| Control group | Patients who have not received regular or continuous anticoagulation therapy due to poor compliance or other reasons. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Observational; No Interventions were given. | Other | Observational; No Interventions were given. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Success rate of thrombolysis | Success rate of thrombolysis within 3 months after initiating anticoagulation therapy. | 1，2，3 months after enrollment. |
| Change of incidence of MACCE | Major adverse cardiovascular and cerebrovascular events, a composite of all-cause mortality, myocardial infarction, coronary revascularization, and stroke. | 1，2，3 months after enrollment. |
| Measure | Description | Time Frame |
|---|---|---|
| Change of incidence of adverse anticoagulation events | Bleeding and thrombotic events | 1，2，3 months after enrollment. |
| Change of incidence of all-cause mortality | All-cause mortality diagnosed by clinical doctors. |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with non-valvular atrial fibrillation who have been diagnosed with intracardiac thrombosis by First Affiliated Hospital of Xi'an Jiaotong University and multiple medical centers, meet the indications for anticoagulation therapy, and are willing to receive anticoagulation therapy.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Guoliang Li | Contact | +8613759982523 | liguoliang_med@163.com | |
| Chaofeng Sun | Contact | cfsun1@mail.xjtu.edu.cn |
| Name | Affiliation | Role |
|---|---|---|
| Guoliang Li | First Affiliated Hospital Xi'an Jiaotong University | Principal Investigator |
| Chaofeng Sun | First Affiliated Hospital Xi'an Jiaotong University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| First Affiliated Hospital of Xian Jiantong University | Xi'an | Shaanxi | 710061 | China |
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| OTHER |
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| 1，2，3 months after enrollment. |
| Change of incidence of myocardial infarction | Myocardial infarction diagnosed by clinical doctors. | 1，2，3 months after enrollment. |
| Change of incidence of coronary revascularization | Coronary revascularization assessed by clinical doctors. | 1，2，3 months after enrollment. |
| Change of incidence of stroke | Stroke diagnosed by clinical doctors. | 1，2，3 months after enrollment. |
| ID | Term |
|---|---|
| D001281 | Atrial Fibrillation |
| ID | Term |
|---|---|
| D001145 | Arrhythmias, Cardiac |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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