An informational video about joining a Research Notification Registry is being compared with a version of the video tailored to African/ African American parents, reminding them about the importance of their being included in clinical trials. African/African American parents and caregivers of children under 13 years of age are targeted.

Improving diversity in research projects and national data repositories is critical to providing safe and effective care to marginalized groups. Unfortunately, certain groups such as African Americans are inadequately represented in much of the available data and in current clinical trials. Recently, investigators have begun employing new messaging approaches to increase diversity in clinical trial enrollment. These messages are typically designed to inform, with no appeal for specific groups to act, and no tailoring that takes into account specific groups. Very little is known about the potential impact of inclusion appeals--direct appeals to historically marginalized groups calling on their need to be included in research studies. Applying the science of appeals to recruitment messages may improve the effectiveness of educational videos and lead to greater participation in research. This pilot study proposes to empirically study whether an inclusion appeal increases decisions to enroll children in studies.

Inclusion:

1. English speaking
2. Self-identified African or African American
3. Not already enrolled in any research participant registry, no history of clinical trial participation
4. At least one child in their care age newborn to 13

Exclusion:

1. Parents with children over the age of 13
2. Non-English speakers
3. Previously enrolled in Children's Hospital of Philadelphia registry, history of clinical trial participation

Adverse events were not monitored in this study, as participation concluded immediately upon completion of the survey. This study was classified as low risk, as it involved only the collection of survey responses without any medical interventions, treatments, or procedures. Given the minimal risk associated with survey-based research, ongoing safety monitoring was not required. Participants were informed that they could discontinue the survey at any time if they experienced discomfort.

Adverse events were not monitored in this study, as participation concluded immediately upon completion of the survey. This study was classified as low risk, as it involved only the collection of survey responses without any medical interventions, treatments, or procedures. Given the minimal risk associated with survey-based research, ongoing safety monitoring was not required. Participants were informed that they could discontinue the survey at any time if they experienced discomfort.

Several factors may affect the interpretation of this study. The sample was drawn from a few urban sites, which could limit the representation of marginalized groups. The fourth study arm was recruited six months later, potentially influencing baseline trust and timing. Participants knew about the incentive before consenting, which may have shaped trust perceptions. Only baseline self-reported data were collected, with no follow-up to assess changes in trust or knowledge after the intervention.