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The goal of this quasi-experimental study is to test effect of time-restricted eating on cognitive function and other biopsychosocial factors in menopausal women undertaking a 12-week exercise programme. The main questions to answer are:
Participants of both groups will have moderate intensity circuit mixed endurance and resistance exercise programme two times per week for 55 minutes for 12 weeks. Participants of one of two groups will not only exercise but also have a time-restricted eating following 16:8 protocol for 12 weeks.
Participants will have pre-tests and post-tests:
Researchers will compare two groups - exercise group and combination group which will do both time-restricted eating and exercise to see if there is a modulating effect of time-restricted eating in participants undertaking exercise.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Exercise and Time-Restricted Eating | Experimental |
| |
| Exercise only | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Exercise and Time-Restricted Eating | Behavioral | Moderate intensity circuit mixed endurance and resistance exercise programme two times per week for 55 minutes for 12 weeks and a time-restricted eating following 16:8 protocol for 12 weeks. |
| Measure | Description | Time Frame |
|---|---|---|
| Brain-derived neurotrophic factor | Level of brain-derived neurotrophic factor in ng/ml | Before and after 12-week intervention |
| Glial cell derived neurotrophic factor | Level of glial cell derived neurotrophic factor in ng/ml | Before and after 12-week intervention |
| Insulin | Level of insulin in μIU/ml | Before and after 12-week intervention |
| Glucose | Level of glucose in mg/dl | Before and after 12-week intervention |
| LDL-cholesterol | Level of cholesterol LDL in mg/dl | Before and after 12-week intervention |
| Muscle mass | Bioelectrical impedance analysis for estimating body composition, in particular muscle mass in kg | Before and after 12-week intervention |
| Fat mass | Bioelectrical impedance analysis for estimating body composition, in particular fat mass in kg | Before and after 12-week intervention |
| Stroop test | Cognitive functions assessment with Stroop test in points. Higher scores means better outcome. |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Poznan University of Physical Education | Poznan | Greater Poland Voivodeship | 61-871 | Poland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40880914 | Derived | Jozwiak B, Kleka P, Laudanska-Krzeminska I. Effect of exercise alone and in combination with time-restricted eating on cognitive health in menopausal women. Front Public Health. 2025 Aug 13;13:1640512. doi: 10.3389/fpubh.2025.1640512. eCollection 2025. | |
| 39434160 | Derived | Jozwiak B, Domin R, Krzywicka M, Laudanska-Krzeminska I. Effect of exercise alone and in combination with time-restricted eating on cardiometabolic health in menopausal women. J Transl Med. 2024 Oct 21;22(1):957. doi: 10.1186/s12967-024-05738-y. |
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| Exercise only | Behavioral | Moderate intensity circuit mixed endurance and resistance exercise programme two times per week for 55 minutes for 12 weeks only. |
|
| Before and after 12-week intervention |
| N-back test | Cognitive functions assessment with N-back test in points. Higher scores means better outcome. | Before and after 12-week intervention |
| Electroencephalography | Measurement of brain waves (alpha, beta, gamma, theta) to assess electrical activity of the brain using Emotiv Epoc X device | Before and after 12-week intervention |
| One-repetition maximum test | Strength assessment with one-repetition maximum test in kg | Before and after 12-week intervention |
| Ruffier test | Cardiorespiratory fitness assessment with Ruffier test in points. Minimum value is 0, maximum value is 10. Higher score means worse outcome. | Before and after 12-week intervention |
| Menopause Rating Scale | Menopausal symptoms assessment with Menopause Rating Scale in points. Minimum value is 0 and maximum value is 44. Higher score means worse outcome. | Before and after 12-week intervention |
| The Menopause-Specific Quality of Life Questionnaire | Menopausal symptoms assessment with The Menopause-Specific Quality of Life Questionnaire in points. Minimum value is 0 and maximum value is 174. Higher score means worse outcome. | Before and after 12-week intervention |
| ID | Term |
|---|---|
| D003072 | Cognition Disorders |
| D008224 | Lymphoma, Follicular |
| ID | Term |
|---|---|
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D008228 | Lymphoma, Non-Hodgkin |
| D008223 | Lymphoma |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D008232 | Lymphoproliferative Disorders |
| D008206 | Lymphatic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D007160 | Immunoproliferative Disorders |
| D007154 | Immune System Diseases |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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