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| Name | Class |
|---|---|
| Avocado Nutrition Center | UNKNOWN |
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The goal of this clinical trial is to determine if adding avocados to the diet of impacts cognition in 70 older adults, age 65-85, without dementia. We will test for change in functional MRI, cognitive performance, and brain blood flow. Intervention group participants will be asked to consume 1 avocado per day for 12 weeks. Participants in the control group will be asked to continue their normal intake for 12 weeks. Throughout the study, participants will be asked to perform cognitive tests, MRI, blood tests, and questionnaires.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Avocado Group | Experimental | Participants will consume 1 avocado per day and receive education to maintain usual caloric intake for 12 weeks and participate in 4 study visits. |
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| No Diet Modification Group | No Intervention | Participants will continue their normal dietary pattern for 12 weeks and participate in 4 study visits. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Avocado Group | Other | Participants will consume provided avocados daily and track consumption for the duration of the study. Participants will be adding avocados to their diet and will receive education on maintaining usual diet. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in brain activity | MRI will be used to measure changes in brain activity during resting state, a working memory task, and executive function task. | Baseline and 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in cerebral blood flow | MRI will be used to measure change in cerebral blood flow. | Baseline and 12 weeks |
| Changes in memory and executive function | NIH Toolbox will be used to measure change in cognition throughout the study. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Emma Kelly, MS | Contact | 913-588-7683 | ekelly9@kumc.edu | |
| Matthew Taylor, PhD | Contact | 913-588-5363 | mtaylor3@kumc.edu |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Kansas Medical Center | Recruiting | Kansas City | Kansas | 66160 | United States |
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Study participants will be randomly assigned equally to either the intervention or the control group.
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Participants cannot be blinded to their allocation in order to follow the study protocol. Investigator and Outcomes Assessor will be blinded.
| Baseline and 12 weeks |