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| ID | Type | Description | Link |
|---|---|---|---|
| R21HD112373-01 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institutes of Health (NIH) | NIH |
| Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | NIH |
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The first aim of this study is to determine the feasibility of delivering CO-OP remotely to individuals experiencing cognitive impairments that limit everyday activities in post-COVID-19 syndrome (PCS). The second aim of this study is to assess the effect of CO-OP on activity performance, subjective and objective cognition, and quality of life in a sample of individuals with PCS. The research team hypothesizes that effect size estimations will indicate that CO-OP will have a greater positive effect, compared to an inactive control group, on activity performance, subjective and objective cognition, and quality of life in a sample of individuals who self-report PCS and cognitive impairment.
Post-COVID-19 symptoms (PCS) cognitive symptoms require the rehabilitation community to investigate ways to: (1) reduce the functional impact of the symptoms on daily life and (2) support individuals with PCS to establish new habits to improve and maintain health. While the cognitive impairment associated with PCS has not been well evaluated, it is similar of cognitive symptoms seen in other conditions. Metacognitive strategy training (MCST) approaches are an evidence-based practice standard for improving capacity to self-manage chronic cognitive symptoms and reduce their functional impact on everyday life activities.
The CO-OP approach is an MCST intervention in which participants are taught a general cognitive strategy that can be applied in known and novel contexts to devise task specific strategies for engaging in an activity. Existing evidence with other populations suggests that CO-OP has more of a positive effect on improving activity performance and cognition than remediation/retraining-based approaches. These effects have been demonstrated in individuals with mild cognitive impairment that mirrors that found in PCS. The overall research hypothesis is that CO-OP can feasibly be administered remotely and will improve activity performance, subjective and objective cognitive function, and quality of life in individuals with PCS.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cognitive Orientation to daily Occupational Performance (CO-OP) | Experimental | Each CO-OP session will last 45 minutes and subjects will complete one session per week over the course of 10 weeks. All sessions will be delivered remotely via the Zoom platform. |
|
| Inactive Control Group | Other | Subjects will complete one session per week over the course of 10 weeks. All sessions will be delivered remotely via the Zoom platform. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| CO-OP Procedures | Behavioral | CO-OP is a metacognitive strategy training intervention that will be used in this study. First, five functional, everyday life goals are identified collaboratively by the participant and interventionist. In the second meeting, we introduce the approach to the subject and teach the global cognitive strategy (i.e., GOAL-PLAN-DO-CHECK). In all subsequent sessions, this strategy is used as the main problem-solving framework to facilitate skill acquisition.The subject identifies a GOAL, and then is guided by the therapist to discover a PLAN to potentially achieve the goal. The subject is then asked to DO the plan (if feasible during the therapy session otherwise asked to complete at home prior to the next treatment session), and subsequently to CHECK to see if the plan worked, i.e. the goal was achieved. This process is repeated until satisfactory performance is met for each established goal. |
| Measure | Description | Time Frame |
|---|---|---|
| Recruitment Rate | Number of participants enrolled divided by number of individuals screened | After study completion, an average of 12 weeks |
| Retention Rate | Number of participants completing all study procedures divided by number of participants enrolled | After study completion, an average of 12 weeks |
| Telehealth Usability Questionnaire (TUQ) | Measure of telehealth usability from participant's perspective. Self-report Likert scale of 1 (disagree) to 7 (agree). Higher values represent a better outcome. | After study completion, an average of 12 weeks |
| Acceptability of Intervention Measure (AIM) | Measure of intervention acceptability. Self-report Likert scale of 1 (completely disagree) to 5 (completely agree) | After study completion, an average of 12 weeks |
| Intervention Appropriateness Measure (IAM) | Measure of intervention appropriateness. Self-report Likert scale of 1 (completely disagree) to 5 (completely agree) | After study completion, an average of 12 weeks |
| Feasibility of Intervention Measure (FIM) | Measure of intervention feasibility. Self-report Likert scale of 1 (completely disagree) to 5 (completely agree) | After study completion, an average of 12 weeks |
| Canadian Occupational Performance Measure (COPM) Performance, Trained Goals |
| Measure | Description | Time Frame |
|---|---|---|
| Delis-Kaplan Executive Function System (DKEFS)- Color-Word Interference, Age-Corrected Time | Objective measure of inhibition and cognitive flexibility. Data are presented for condition 4 of color/word switching. Age-adjusted scale scores are presented with a mean of 10 and a standard deviation of 3. Maximum=19, minimum=1. Higher scores indicate better performance. | Pre-intervention (week 0) and post-intervention (week 12) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Anna E Boone, PhD, OTR/L | University of Missouri Occupational Therapy | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Missouri Department of Occupational Therapy | Columbia | Missouri | 65211 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25416738 | Background | McEwen S, Polatajko H, Baum C, Rios J, Cirone D, Doherty M, Wolf T. Combined Cognitive-Strategy and Task-Specific Training Improve Transfer to Untrained Activities in Subacute Stroke: An Exploratory Randomized Controlled Trial. Neurorehabil Neural Repair. 2015 Jul;29(6):526-36. doi: 10.1177/1545968314558602. Epub 2014 Nov 21. | |
| 18030634 | Background | Geusgens CA, van Heugten CM, Cooijmans JP, Jolles J, van den Heuvel WJ. Transfer effects of a cognitive strategy training for stroke patients with apraxia. J Clin Exp Neuropsychol. 2007 Nov;29(8):831-41. doi: 10.1080/13803390601125971. |
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One participant was enrolled and signed written consent but withdrew during baseline assessment. Therefore, this participant was never randomized.
Dates of the recruitment period: February 2024-April 2025 Types of recruitment: email newsletters, social media posts (Facebook, Instagram, Twitter), flyers in the community, websites (Research Match, University of Missouri Research, Innovation, & Impact).
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| ID | Title | Description |
|---|---|---|
| FG000 | Cognitive Orientation to Daily Occupational Performance (CO-OP) | Each CO-OP session will last 45 minutes and subjects will complete one session per week over the course of 10 weeks. All sessions will be delivered remotely via the Zoom platform. |
| FG001 | Inactive Control Group | Subjects will complete one session per week over the course of 10 weeks. All sessions will be delivered remotely via the Zoom platform. |
| Title | Milestones | Reasons Not Completed | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
|
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| ID | Title | Description |
|---|---|---|
| BG000 | Cognitive Orientation to Daily Occupational Performance (CO-OP) | Each CO-OP session will last 45 minutes and subjects will complete one session per week over the course of 10 weeks. All sessions will be delivered remotely via the Zoom platform. |
| BG001 | Inactive Control Group |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Continuous | Mean |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Recruitment Rate | Number of participants enrolled divided by number of individuals screened | Posted | Count of Participants | Participants | After study completion, an average of 12 weeks |
|
|
Through study completion, up to 12 weeks
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Cognitive Orientation to Daily Occupational Performance (CO-OP) | Each CO-OP session will last 45 minutes and subjects will complete one session per week over the course of 10 weeks. All sessions will be delivered remotely via the Zoom platform. |
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| Term | Organ System | Source Vocabulary | Assessment Type | Notes | Statistical Information |
|---|---|---|---|---|---|
| ER Visit | General disorders | Non-systematic Assessment | Pt visited emergency room due to panic attack resulting in increased heart rate. No intervention was required. Pt's treatment schedule was not disrupted. |
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Anna Boone, PhD | University of Missouri | 573-882-7023 | booneae@umsystem.edu |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP_ICF | Yes | Yes | Yes | Study Protocol, Statistical Analysis Plan, and Informed Consent Form: Study Protocol, including SAP and ICF | Feb 11, 2025 | Jan 28, 2026 | Prot_SAP_ICF_001.pdf |
| ICF | No | No | Yes | Informed Consent Form: Informed Consent Form Only | May 1, 2023 | Sep 18, 2025 | ICF_000.pdf |
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| ID | Term |
|---|---|
| D000094024 | Post-Acute COVID-19 Syndrome |
| D000086382 | COVID-19 |
| ID | Term |
|---|---|
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
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After baseline assessment, subjects will be randomized to one of two groups: (1) a 10-session Cognitive Orientation to daily Occupational Performance (CO-OP) intervention; or (2) a 10-session inactive control group.
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All outcomes assessors will be blinded to participant study group assignment.
|
| Inactive Control Group | Behavioral | An inactive control group will be used to control for maturation and testing effects. Weekly contact will be made via teleconferencing to (1) maintain study engagement, (2) introduce weekly social contact with researchers, mimicking some of the potential incidental effects of the experimental group, and (3) ascertain what, if any, additional steps participants have taken to reduce PCS symptoms. The content of each of these meetings will be tracked in intervention notes. Each contact will be recorded for fidelity monitoring to ensure all active ingredients of the CO-OP intervention are avoided. |
|
Self-report measure of activity performance. Minimum = 1, Maximum = 10. Higher scores mean better performance.
| Pre-intervention (week 0) and post-intervention (week 12) |
| Canadian Occupational Performance Measure (COPM) Satisfaction, Trained Goals | Self-report measure of satisfaction level with activity performance. Minimum = 1, Maximum = 10. Higher scores mean higher satisfaction. | Pre-intervention (week 0) and post-intervention (week 12) |
| Delis-Kaplan Executive Function System (DKEFS)- Color-Word Interference, Age-Corrected Errors | Objective measure of inhibition and cognitive flexibility. Data are presented for condition 4 of color/word switching. Age-adjusted scale scores are presented with a mean of 10 and a standard deviation of 3. Maximum=19, minimum=1. Higher scores indicate better performance. | Pre-intervention (week 0) and post-intervention (week 12) |
| Patient-Reported Outcomes Measurement Information System (PROMIS) Cognitive Function | Self-report measure of cognition. Maximum=5, minimum=1. T-scores are reported with a mean of 50 and a standard deviation of 10. Higher scores indicate fewer perceived cognitive deficits. | Pre-intervention (week 0) and post-intervention (week 12) |
| Cambridge Neuropsychological Test Automated Battery (CANTAB) Rapid Visual Information Processing Subtest | Objective measure of sustained attention. A Z-score of 0 represents the population mean. Higher scores indicate better performance. | Pre-intervention (week 0) and post-intervention (week 12) |
| CANTAB Spatial Working Memory Subtest | Objective measure of working memory and strategy. A Z-score of 0 represents the population mean. Higher scores indicate better performance. | Pre-intervention (week 0) and post-intervention (week 12) |
| CANTAB Stockings of Cambridge Subtest | Objective measure of planning and executive function. A Z-score of 0 represents the population mean. Higher scores indicate better performance. | Pre-intervention (week 0) and post-intervention (week 12) |
| CANTAB Delayed Matching to Sample Subtest | Objective measure of short-term visual recognition memory and attention. A Z-score of 0 represents the population mean. Higher scores indicate better performance. | Pre-intervention (week 0) and post-intervention (week 12) |
| CANTAB Paired Associates Learning Subtest | Objective measure of visual episodic memory. A Z-score of 0 represents the population mean. Higher scores indicate better performance. | Pre-intervention (week 0) and post-intervention (week 12) |
| Canadian Occupational Performance Measure (COPM) Performance, Untrained Goals | Self-report measure of activity performance. Minimum = 1, Maximum = 10. Higher scores mean better performance. | Pre-intervention (week 0) and post-intervention (week 12) |
| Canadian Occupational Performance Measure (COPM) Satisfaction, Untrained Goals | Self-report measure of satisfaction level with activity performance. Minimum = 1, Maximum = 10. Higher scores mean higher satisfaction. | Pre-intervention (week 0) and post-intervention (week 12) |
| World Health Organization Quality of Life Assessment Instrument (WHOQOL-100) - Physical Domain | Self-report measure of physical health. Each item is ranked on a Likert scale of 1-5 (Maximum=5, minimum=1). The range of scores for this domain is 0-100, with higher scores indicating greater perceived physical health. | Pre-intervention (week 0) and post-intervention (week 12) |
| World Health Organization Quality of Life Assessment Instrument (WHOQOL-100) - Social Domain | Self-report measure of social health. Each item is ranked on a Likert scale of 1-5 (Maximum=5, minimum=1). The range of scores for this domain is 0-100, with higher scores indicating greater perceived social health. | Pre-intervention (week 0) and post-intervention (week 12) |
| World Health Organization Quality of Life Assessment Instrument (WHOQOL-100) - Environmental Domain | Self-report measure of environmental health. Each item is ranked on a Likert scale of 1-5 (Maximum=5, minimum=1). The range of scores for this domain is 0-100, with higher scores indicating greater perceived environmental health. | Pre-intervention (week 0) and post-intervention (week 12) |
| World Health Organization Quality of Life Assessment Instrument (WHOQOL-100) - Spiritual Domain | Self-report measure of spiritual health. Each item is ranked on a Likert scale of 1-5 (Maximum=5, minimum=1). The range of scores for this domain is 0-100, with higher scores indicating greater perceived spiritual health. | Pre-intervention (week 0) and post-intervention (week 12) |
| World Health Organization Quality of Life Assessment Instrument (WHOQOL-100) - Independence Domain | Self-report measure of independence. Each item is ranked on a Likert scale of 1-5 (Maximum=5, minimum=1). The range of scores for this domain is 0-100, with higher scores indicating greater perceived independence. | Pre-intervention (week 0) and post-intervention (week 12) |
| World Health Organization Quality of Life Assessment Instrument (WHOQOL-100) - Psychological Domain | Self-report measure of psychological health. Each item is ranked on a Likert scale of 1-5 (Maximum=5, minimum=1). The range of scores for this domain is 0-100, with higher scores indicating greater perceived psychological health. | Pre-intervention (week 0) and post-intervention (week 12) |
| Cognitive Failures Questionnaires Total Score | Self-report measure of frequency of cognitive errors in daily life. Participants rate each item on a scale of 0 (never) to 4 (very often). Maximum total score=100, minimum total score=0. Higher scores indicate increased perceived cognitive errors. | Pre-intervention (week 0) and post-intervention (week 12) |
| Background | Haskins EC, Cicerone KD, Trexler LE. Cognitive rehabilitation manual: Translating evidence-based recommendations into practice. ACRM Publishing; 2012. |
| 16084827 | Background | Cicerone KD, Dahlberg C, Malec JF, Langenbahn DM, Felicetti T, Kneipp S, Ellmo W, Kalmar K, Giacino JT, Harley JP, Laatsch L, Morse PA, Catanese J. Evidence-based cognitive rehabilitation: updated review of the literature from 1998 through 2002. Arch Phys Med Rehabil. 2005 Aug;86(8):1681-92. doi: 10.1016/j.apmr.2005.03.024. |
| 19892074 | Background | Dawson DR, Anderson ND, Burgess P, Cooper E, Krpan KM, Stuss DT. Further development of the Multiple Errands Test: standardized scoring, reliability, and ecological validity for the Baycrest version. Arch Phys Med Rehabil. 2009 Nov;90(11 Suppl):S41-51. doi: 10.1016/j.apmr.2009.07.012. |
| 26943113 | Background | Wolf TJ, Polatajko H, Baum C, Rios J, Cirone D, Doherty M, McEwen S. Combined Cognitive-Strategy and Task-Specific Training Affects Cognition and Upper-Extremity Function in Subacute Stroke: An Exploratory Randomized Controlled Trial. Am J Occup Ther. 2016 Mar-Apr;70(2):7002290010p1-7002290010p10. doi: 10.5014/ajot.2016.017293. |
Subjects will complete one session per week over the course of 10 weeks. All sessions will be delivered remotely via the Zoom platform. |
| BG002 | Total | Total of all reporting groups |
| years |
|
| Sex/Gender, Customized | Count of Participants | Participants |
|
| Race (NIH/OMB) | Count of Participants | Participants |
|
| Ethnicity (NIH/OMB) | Count of Participants | Participants |
|
| Region of Enrollment | Number | Participants |
|
| Education | Mean | Standard Deviation | years |
|
| Time Post-COVID Diagnosis | Mean | Standard Deviation | months |
|
|
| Primary | Retention Rate | Number of participants completing all study procedures divided by number of participants enrolled | Posted | Count of Participants | Participants | After study completion, an average of 12 weeks |
|
|
|
| Primary | Telehealth Usability Questionnaire (TUQ) | Measure of telehealth usability from participant's perspective. Self-report Likert scale of 1 (disagree) to 7 (agree). Higher values represent a better outcome. | Posted | Mean | Standard Deviation | units on a scale | After study completion, an average of 12 weeks |
|
|
|
| Primary | Acceptability of Intervention Measure (AIM) | Measure of intervention acceptability. Self-report Likert scale of 1 (completely disagree) to 5 (completely agree) | Posted | Mean | Standard Deviation | units on a scale | After study completion, an average of 12 weeks |
|
|
|
| Primary | Intervention Appropriateness Measure (IAM) | Measure of intervention appropriateness. Self-report Likert scale of 1 (completely disagree) to 5 (completely agree) | Posted | Mean | Standard Deviation | units on a scale | After study completion, an average of 12 weeks |
|
|
|
| Primary | Feasibility of Intervention Measure (FIM) | Measure of intervention feasibility. Self-report Likert scale of 1 (completely disagree) to 5 (completely agree) | Posted | Mean | Standard Deviation | units on a scale | After study completion, an average of 12 weeks |
|
|
|
| Primary | Canadian Occupational Performance Measure (COPM) Performance, Trained Goals | Self-report measure of activity performance. Minimum = 1, Maximum = 10. Higher scores mean better performance. | Posted | Mean | Standard Deviation | units on a scale | Pre-intervention (week 0) and post-intervention (week 12) |
|
|
|
|
| Secondary | Delis-Kaplan Executive Function System (DKEFS)- Color-Word Interference, Age-Corrected Time | Objective measure of inhibition and cognitive flexibility. Data are presented for condition 4 of color/word switching. Age-adjusted scale scores are presented with a mean of 10 and a standard deviation of 3. Maximum=19, minimum=1. Higher scores indicate better performance. | Posted | Mean | Standard Deviation | units on a scale | Pre-intervention (week 0) and post-intervention (week 12) |
|
|
|
|
| Secondary | Delis-Kaplan Executive Function System (DKEFS)- Color-Word Interference, Age-Corrected Errors | Objective measure of inhibition and cognitive flexibility. Data are presented for condition 4 of color/word switching. Age-adjusted scale scores are presented with a mean of 10 and a standard deviation of 3. Maximum=19, minimum=1. Higher scores indicate better performance. | Posted | Mean | Standard Deviation | units on a scale | Pre-intervention (week 0) and post-intervention (week 12) |
|
|
|
|
| Secondary | Patient-Reported Outcomes Measurement Information System (PROMIS) Cognitive Function | Self-report measure of cognition. Maximum=5, minimum=1. T-scores are reported with a mean of 50 and a standard deviation of 10. Higher scores indicate fewer perceived cognitive deficits. | Posted | Mean | Standard Deviation | T-score | Pre-intervention (week 0) and post-intervention (week 12) |
|
|
|
|
| Secondary | Cambridge Neuropsychological Test Automated Battery (CANTAB) Rapid Visual Information Processing Subtest | Objective measure of sustained attention. A Z-score of 0 represents the population mean. Higher scores indicate better performance. | Posted | Mean | Standard Deviation | Z-score | Pre-intervention (week 0) and post-intervention (week 12) |
|
|
|
|
| Secondary | CANTAB Spatial Working Memory Subtest | Objective measure of working memory and strategy. A Z-score of 0 represents the population mean. Higher scores indicate better performance. | Posted | Mean | Standard Deviation | Z-score | Pre-intervention (week 0) and post-intervention (week 12) |
|
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|
|
| Secondary | CANTAB Stockings of Cambridge Subtest | Objective measure of planning and executive function. A Z-score of 0 represents the population mean. Higher scores indicate better performance. | Posted | Mean | Standard Deviation | Z-score | Pre-intervention (week 0) and post-intervention (week 12) |
|
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|
|
| Secondary | CANTAB Delayed Matching to Sample Subtest | Objective measure of short-term visual recognition memory and attention. A Z-score of 0 represents the population mean. Higher scores indicate better performance. | Posted | Mean | Standard Deviation | Z-score | Pre-intervention (week 0) and post-intervention (week 12) |
|
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|
| Secondary | CANTAB Paired Associates Learning Subtest | Objective measure of visual episodic memory. A Z-score of 0 represents the population mean. Higher scores indicate better performance. | Posted | Mean | Standard Deviation | Z-score | Pre-intervention (week 0) and post-intervention (week 12) |
|
|
|
|
| Primary | Canadian Occupational Performance Measure (COPM) Satisfaction, Trained Goals | Self-report measure of satisfaction level with activity performance. Minimum = 1, Maximum = 10. Higher scores mean higher satisfaction. | Posted | Mean | Standard Deviation | units on a scale | Pre-intervention (week 0) and post-intervention (week 12) |
|
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| Secondary | Canadian Occupational Performance Measure (COPM) Performance, Untrained Goals | Self-report measure of activity performance. Minimum = 1, Maximum = 10. Higher scores mean better performance. | Posted | Mean | Standard Deviation | units on a scale | Pre-intervention (week 0) and post-intervention (week 12) |
|
|
|
|
| Secondary | Canadian Occupational Performance Measure (COPM) Satisfaction, Untrained Goals | Self-report measure of satisfaction level with activity performance. Minimum = 1, Maximum = 10. Higher scores mean higher satisfaction. | Posted | Mean | Standard Deviation | units on a scale | Pre-intervention (week 0) and post-intervention (week 12) |
|
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| Secondary | World Health Organization Quality of Life Assessment Instrument (WHOQOL-100) - Physical Domain | Self-report measure of physical health. Each item is ranked on a Likert scale of 1-5 (Maximum=5, minimum=1). The range of scores for this domain is 0-100, with higher scores indicating greater perceived physical health. | Posted | Mean | Standard Deviation | units on a scale | Pre-intervention (week 0) and post-intervention (week 12) |
|
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|
|
| Secondary | World Health Organization Quality of Life Assessment Instrument (WHOQOL-100) - Social Domain | Self-report measure of social health. Each item is ranked on a Likert scale of 1-5 (Maximum=5, minimum=1). The range of scores for this domain is 0-100, with higher scores indicating greater perceived social health. | Posted | Mean | Standard Deviation | units on a scale | Pre-intervention (week 0) and post-intervention (week 12) |
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| Secondary | World Health Organization Quality of Life Assessment Instrument (WHOQOL-100) - Environmental Domain | Self-report measure of environmental health. Each item is ranked on a Likert scale of 1-5 (Maximum=5, minimum=1). The range of scores for this domain is 0-100, with higher scores indicating greater perceived environmental health. | Posted | Mean | Standard Deviation | units on a scale | Pre-intervention (week 0) and post-intervention (week 12) |
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| Secondary | World Health Organization Quality of Life Assessment Instrument (WHOQOL-100) - Spiritual Domain | Self-report measure of spiritual health. Each item is ranked on a Likert scale of 1-5 (Maximum=5, minimum=1). The range of scores for this domain is 0-100, with higher scores indicating greater perceived spiritual health. | Posted | Mean | Standard Deviation | units on a scale | Pre-intervention (week 0) and post-intervention (week 12) |
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| Secondary | World Health Organization Quality of Life Assessment Instrument (WHOQOL-100) - Independence Domain | Self-report measure of independence. Each item is ranked on a Likert scale of 1-5 (Maximum=5, minimum=1). The range of scores for this domain is 0-100, with higher scores indicating greater perceived independence. | Posted | Mean | Standard Deviation | units on a scale | Pre-intervention (week 0) and post-intervention (week 12) |
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| Secondary | World Health Organization Quality of Life Assessment Instrument (WHOQOL-100) - Psychological Domain | Self-report measure of psychological health. Each item is ranked on a Likert scale of 1-5 (Maximum=5, minimum=1). The range of scores for this domain is 0-100, with higher scores indicating greater perceived psychological health. | Posted | Mean | Standard Deviation | units on a scale | Pre-intervention (week 0) and post-intervention (week 12) |
|
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| Secondary | Cognitive Failures Questionnaires Total Score | Self-report measure of frequency of cognitive errors in daily life. Participants rate each item on a scale of 0 (never) to 4 (very often). Maximum total score=100, minimum total score=0. Higher scores indicate increased perceived cognitive errors. | Posted | Mean | Standard Deviation | units on a scale | Pre-intervention (week 0) and post-intervention (week 12) |
|
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|
| 0 |
| 21 |
| 0 |
| 21 |
| 1 |
| 21 |
| EG001 | Inactive Control Group | Subjects will complete one session per week over the course of 10 weeks. All sessions will be delivered remotely via the Zoom platform. | 0 | 27 | 0 | 27 | 0 | 27 |
|
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| D014777 |
| Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D000094025 | Post-Infectious Disorders |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |