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| Name | Class |
|---|---|
| Polish Cardiac Society | OTHER |
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The study aims to evaluate composition differences of aortic valves in different stages and phenotypes of aortic stenosis using non-invasive imaging and histology.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Severe Aortic Stenosis - High Flow, High Gradient | patients undergoing surgical aortic valve replacement for severe AS | ||
| Severe Aortic Stenosis - classical Low Flow, Low Gradient | patients undergoing surgical aortic valve replacement for severe AS | ||
| Severe Aortic Stenosis - paradoxical Low Flow, Low Gradient | patients undergoing surgical aortic valve replacement for severe AS | ||
| Moderate Aortic Stenosis | patients undergoing aortic root replacement (Bentall procedure) | ||
| Heart Transplant | patients undergoing orthotopic heart transplant for any reason |
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| Measure | Description | Time Frame |
|---|---|---|
| Aortic valve tissue composition measured from pre-procedural computed tomography angiography | Quantitative analysis of aortic valve composition will be based on pre-surgical planning CTA images using semi-automated software (Autoplaque version 2.5, Cedars-Sinai Medical Center, Los Angeles, CA, USA) for calcified, non-calcified and total tissue volumes. | up to 30-days before surgery |
| Aortic valve tissue composition measured from quantitative histology | Different stains will be used to characterize composition of excised aortic valves (hematoxylin and eosin, Movat Pentachrome, Van Gieson's trichrome, Congo Red, anti-CD68 antibody | immediately post-surgery |
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Inclusion Criteria:
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The study will involve patients undergoing surgical aortic valve replacement (SAVR) for different phenotypes of severe AS (high-flow high-gradient, classical low-flow low-gradient, and paradoxical low-flow low-gradient) or moderate AS with coexisting aortic aneurysm as part of Bentall procedure. Patients undergoing heart transplant will be considered control group without aortic valve stenosis.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Kajetan Grodecki, MD, PhD | Contact | 0048 660675782 | kajetan.grodecki@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Zenon Huczek, MD,PhD | Medical University of Warsaw | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Medical University of Silesia | Recruiting | Katowice | Poland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33247903 | Background | Grodecki K, Tamarappoo BK, Huczek Z, Jedrzejczyk S, Cadet S, Kwiecinski J, Rymuza B, Parma R, Olasinska-Wisniewska A, Fijalkowska J, Protasiewicz M, Walczak A, Nowak A, Gocol R, Slomka PJ, Reczuch K, Jagielak D, Grygier M, Wojakowski W, Filipiak KJ, Dey D. Non-calcific aortic tissue quantified from computed tomography angiography improves diagnosis and prognostication of patients referred for transcatheter aortic valve implantation. Eur Heart J Cardiovasc Imaging. 2021 May 10;22(6):626-635. doi: 10.1093/ehjci/jeaa304. |
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| ID | Term |
|---|---|
| D001024 | Aortic Valve Stenosis |
| D000082862 | Aortic Valve Disease |
| C562942 | Aortic Valve, Calcification of |
| ID | Term |
|---|---|
| D006349 | Heart Valve Diseases |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D014694 | Ventricular Outflow Obstruction |
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leaflets of each aortic valve excised at the time of surgery will be separately placed in a pre-filled container with 10% neutral, phosphate-buffered formalin
| Poznan University of Medical Sciences | Recruiting | Poznan | Poland |
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