Introduction: The placement of a peripheral inserted central catheter (PICC) is a common practice in the hospital setting. However, despite all the advances reported, venous devices are not free of complications and catheter-related thrombosis (CRT), being one of the most prevalent. Electro muscular stimulation therapy can be a measure for the prevention of CRT. Objective: To know the efficacy of electro muscular stimulation therapy in patients hospitalized in critical care units to prevent venous thrombosis related to PICC catheters. Methodology: A multicenter Randomized Clinical Trial (RCT) will be carried out at the Dr. Josep Trueta University Hospital in Girona, Hospital del Mar in Barcelona, Althaia Foundation in Manresa. With a total of 68 patients with PICC catheters in critical care units, they will be randomly assigned to the intervention group (n=34) to whom, in addition to the usual protocolized care related to the vascular catheter, will be applied e Eco-EMS protocol, or the control group (n=34) to which only the usual protocolized care related to the vascular catheter was applied. Intervention: It will consist of the application of electrostimulation therapy five days a week, two daily sessions of 20 minutes in the intervention group. Both groups underwent five ultrasound examinations after the placement of the PICC to determine the appearance of CRT. Expected results: It is expected to observe that the application of the Eco-EMS protocol reduces thrombosis in the patients of the intervention group, compared to those of the control group.

Inclusion Criteria:

• Patients admitted to the critical unit with a PICC whose insertion is done by the EIAV of the same hospital.
• Patients between 18 and 80 years of age.
• Treatments related to the device protocolized by the same hospital as the EIAV implanter.

Exclusion Criteria:

• Patients who do not sign informed consent.
• Patients with pacemakers and/or implantable automatic defibrillators.
• Patients with epilepsy.
• Removal of the device within the first 15 days after insertion.
• Hospital discharge, transfer to another hospital or death lethalis during the duration of the study.
• Displacement of the tip of the catheter outside the lower ⅓ of the superior vein cava during the study period.
• Presence of lesions in the place where the electrodes must be placed to perform the electrostimulation therapy.
• Non-compliance with catheter monitoring: Of the five ultrasound controls protocolized in the study, 80% were not complied with.