A double-blind placebo-controlled trial is conducted in order to evaluate the efficacy of Fluocinonide 0,05% and determinate the statistical significance of the outcome variables. Oral cavity lichen is a chronic inflammatory condition affecting the mucosa of the oral cavity , which significantly reduces the quality of life of affected individuals.

A double-blind placebo-controlled study was conducted to evaluate the clinical efficacy of Fluocinonide 0.05% oral gel and determine the statistical significance of outcome variables.

20 patients with Oral Lichen Planus were divided by a randomization system, into two groups: case group treated with Fluocinonide 0.05% oral gel and applied to oral lesions 2 times a day for 1 month and a placebo group as a control group; with 2 months of follow-up.

Inclusion Criteria:

• Clinical and histologic diagnosis of Lichen Planus Orale;
• Presence of symptoms related to Lichen Planus Orale;
• Clinical follow-up period of at least 12 weeks;
• Acceptance of informed consent

Exclusion Criteria:

• State of pregnancy or lactation; h
• Histologic signs of dysplasia;
• Medications that induce a lichenoid response (ACE inhibitors, β-blockers, etc.);
• Presence of amalgam fillings in the vicinity of lesions;
• Treatment of oral lichen in the previous 6 months from the start of the program;
• Presence of extraoral lesions (genital, skin, etc.);
• Diabetes being treated with oral hypoglycemic drugs;
• History of previous immunodeficiency;
• HIV seropositivity;
• Previous allogeneic bone marrow transplantation;
• Diagnosis of LES or other autoimmune disease

3 months

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