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Dermogenesis With Mesenchymal Stem Cells in treating Post Acne Depressed Spots
management at two different stages of the course of the disease. First one at the stage of active disease which needs cleansers, antibiotics, retinoids, anti inflammatory agents and hormonal manipulation. Once active disease is over, patients report to clinician with depressed spots which are caused by localized dermal disruption and fat atrophy post inflammation or spontaneous epithelial rupture or scratching by the patient. These acne spots are hard to treat due to many reasons. Firstly, excision is difficult as size of most of them is small and they are in a large in number. Secondly, filling with and without subcision is not adequately addressing the deformity. Currently, a combination of filling with synthetic filler or fat and resurfacing by peeling, LASER or dermabrasion is in practice. In-spite of all, a treatment is still required to address post acne spots (Ice Spec Spots) adequately.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Mesenchymal stem cells | Experimental | Mesenchymal Stem Cells taken from adipose tissue will be used |
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| Homogenized fat | Experimental | Adipose tissue will be harvested and used |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Autologous Mesenchymal stem cells injection | Procedure | Autologous Mesenchymal stem cells will be seperated from harvested fat and injected in acne scars |
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| Measure | Description | Time Frame |
|---|---|---|
| Dermal thickness | on microscopy of biopsy section | 3 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| King Edward Medical University | Lahore | Punjab Province | 54000 | Pakistan |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41078325 | Derived | Bashir A, Choudhery MS, Afzaal S, Ali S, Afzaal S. Adipose Tissue-Derived Stem Cells Enhance Dermogenesis of Post-Acne Depressed Spots. J Cosmet Dermatol. 2025 Oct;24(10):e70399. doi: 10.1111/jocd.70399. |
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Cumulative ananlysis
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Group A with MSCs Group B with Fat
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| Homogenized fat injection | Procedure | Autologous fat will be harvested, homogenized and injected. |
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