Ultrasonic Neuromodulation for Treatment of PTSD

Deep Brain Therapy With Low-intensity Ultrasound for Treatment of Post-traumatic Stress Disorder

This study will evaluate a new form of non-invasive deep brain therapy for individuals with post-traumatic stress disorder (PTSD). Low-intensity transcranial focused ultrasound stimulation will first be delivered using a range of stimulation parameters during psychophysical and physiological monitoring. A well-tolerated stimulation protocol will be selected for subsequent testing in a blinded randomized sham-controlled cross-over trial. The trial will evaluate brain target engagement using magnetic resonance imaging and numerical scales of PTSD, cognitive performance, and mood.

Inclusion Criteria:

• Positive PTSD diagnosis; PCL-5 > 20

Exclusion Criteria:

• Inability to complete MRI
• Suicidal ideation