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This prospective randomized trial will compare outcomes in patients receiving aspirin in combination with a low-molecular weight heparin and those under this center's standard protocol receiving neither medication, in order to determine if these medications may improve success rates.
This prospective randomized trial will compare outcomes in patients receiving aspirin (81mg daily) in combination with a low-molecular weight heparin (LMWH) (enoxaparin (Lovenox®), 40mg daily subcutaneous injection) and those under this center's standard protocol receiving neither medication, in order to determine if these medications may improve success rates.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Treatment Arm | Experimental | Patients randomized to receive aspirin and Lovenox will begin taking one "low dose" 81mg aspirin and one 40mg injection of Lovenox daily, on the day of progesterone start. |
|
| Control Arm | Active Comparator | This arm receives neither medication. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Lovenox | Drug | A low-molecular-weight heparin, 40mg daily injection. |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Serum hCG level | Serum hCG level | 5 days post transfer |
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Inclusion Criteria:
Exclusion Criteria:
Female seeking pregnancy.
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Shironda Anderson | Contact | 702-254-1777 | shironda@fertilitycenterlv.com |
| Name | Affiliation | Role |
|---|---|---|
| Bruce Shapiro, MD, PhD | Fertility Center of Las Vegas | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Fertility center of Las Vegas | Recruiting | Las Vegas | Nevada | 89117 | United States |
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| ID | Term |
|---|---|
| D007247 | Infertility, Female |
| ID | Term |
|---|---|
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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| ID | Term |
|---|---|
| D017984 | Enoxaparin |
| D001241 | Aspirin |
| D004624 | Embryo Transfer |
| ID | Term |
|---|---|
| D006495 | Heparin, Low-Molecular-Weight |
| D006493 | Heparin |
| D006025 | Glycosaminoglycans |
| D011134 | Polysaccharides |
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Randomized trial comparing treatment to controls.
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| Aspirin |
| Drug |
Aspirin 81mg daily tablet. |
|
| Embryo transfer | Procedure | Embryo transfer |
|
| D000091662 | Genital Diseases |
| D007246 | Infertility |
| D002241 |
| Carbohydrates |
| D012459 | Salicylates |
| D062385 | Hydroxybenzoates |
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |
| D027724 | Reproductive Techniques, Assisted |
| D012099 | Reproductive Techniques |
| D013812 | Therapeutics |
| D008919 | Investigative Techniques |