Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The objective of the study is to evaluate the performance of muscle ultrasound sections on antenatal ultrasound between 21-24 amenorrhea weeks for the screening of muscle atrophy, in a sample of low-risk and high-risk pregnancies of congenital multiple arthrogryposis
Frequent rare diseases (100-200 births in France / year), congenital multiple arthrogryposis include a set of pathologies characterized by the limitation of joint movements at least two joint levels.Their functional prognosis and muscle atrophy are often severe after birth.
Routine ultrasound call signs are either non-specific or insensitive and difficult to detect due to time constraints. Antenatal ultrasound screening is not very effective for these pathologies, which are often particularly serious.
The main criterion will be the success rate of realization of all four ultrasound sections at the extremities (deltoide, biceps, quadriceps, triceps) and measurements of the distances "skin - muscle fascia" and "muscular fascia - periosteum" between 21-24 amenorrhea weeks
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| high risk of Arthrogryposis AMC | Active Comparator | Patient with a diagnosis during the 1st, 2nd, or 3rd trimester ultrasound, of an abnormality of position / deformation of one or more joints, and / or an abnormality of fetal movements at screening ultrasound or interrogation |
|
| low risk of Arthrogryposis AMC | Active Comparator | Patient coming for screening ultrasound |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| ultrasound muscle imaging technique | Diagnostic Test | ultrasound muscle imaging technique in antenatal ultrasound screening of congenital multiple arthrogryposis |
|
| Measure | Description | Time Frame |
|---|---|---|
| Rate of achievement (success) of all four sections at the extremities | Rate of achievement (success) of all four sections at the extremities for measurements (in mm) of the distances "skin - muscular aponeurosis" and "muscular aponeurosis- periosteum" between 21-24 amenorrhea weeks | 72 hours +/- 24 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Rate of achievement (success) of each four sections | Rate of achievement (success) of measurements (in mm) of the distances "skin - muscular aponeurosis" and "muscular aponeurosis- periosteum" between 21-24 amenorrhea weeks for biceps, deltoide, quadriceps and sural triceps | 72 hours +/- 24 hours |
| Collect the raisons for the failure of achievement of all sections |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Pregnant woman
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Lora PEJOT, Midwife | Contact | 0476766561 | lpejot@chu-grenoble.fr |
| Name | Affiliation | Role |
|---|---|---|
| Klaus DIETERICH, MD,PhD | Univ. Grenoble Alpes Inserm U1209 IAB CHU Grenoble Alpes | Principal Investigator |
Not provided
Not provided
| ID | Term |
|---|---|
| D001176 | Arthrogryposis |
| ID | Term |
|---|---|
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
| D009135 | Muscular Diseases |
| D009139 | Musculoskeletal Abnormalities |
Not provided
Not provided
study prospective,randomized ,two groups (low risk of AMC vs hight risk of AMC), multicentre
Not provided
Not provided
Not provided
Not provided
Collect the raisons for the failure of achievement of all sections (Inadequate foetal position,Insufficient echogenicity, Reasons related to the position of the limbs (full extension or flexion of the elbows or knees, abduction of the shoulder, other), other raison (to be specified) |
| 72 hours +/- 24 hours |
| Duration of realization of the ultrasound sections | Duration of realization of the ultrasound sections (investigators make an hypotheses of a duration of 3 minutes necessary for the realization of the sections | 72 hours +/- 24 hours |
| Comparison of the completion rates of all cuts during ultrasounds between high- and low-risk patients | Comparison of the completion rates of all cuts during ultrasounds between high- and low-risk patients | 72 hours +/- 24 hours |
| Concordance of measures (CCI coefficient) will be evaluated in intra-observer and inter-observer respectively | Concordance of measures (CCI coefficient) will be evaluated in intra-observer and inter-observer respectively by dividing by half the high-risk pregnancies, to whom it will be proposed a 2nd ultrasound of the 2nd trimester, within 3 days (±24) hours by the same / another referent sonographer in the same center. A group of 30 low-risk pregnancies will be evaluated in the same way, with the study of intra-observer reproducibility in 15. The sample of 30 pregnancies in which two measurements are made makes it possible to obtain a lower bound of the 95% confidence interval of the intra-class correlation coefficient greater than 0.7, if this coefficient is 0.85 or more. This threshold is usually considered to reflect a satisfactory concordance. | 72 hours +/- 24 hours |
| D000013 | Congenital Abnormalities |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |