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An Exploration of Candidates for Neoadjuvant Treatment in Resectable Pancreatic Cancer
The 1,132 patients with resectable or borderline resectable PDAC who underwent surgery between 2007 and 2021 were retrospectively reviewed. Patients with resectable PDAC without contact of major vessels (R-no contact) (n=651), with contact of portal vein or superior mesenteric vein (PV/SMV) ≤180° (R-contact) (n=306), and borderline resectable PDAC without arterial involvement (BR-V) (n=175) were analyzed.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| resectable PDAC with no contact to major vessels (R-no contact) |
| ||
| resectable PDAC with contact PV/SMV of ≤180° (R-contact) |
| ||
| borderline resectable PDAC with PV/SMV contact >180° and without arterial involvement (BR-V) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Neoadjuvant treatment | Drug | Intravenous gemcitabine-based combination regimens or FOLFIRINOX were included in NAC. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Overall survival | the time from diagnosis to death from any cause or the date of the last visit | From the date when biopsy results came out until the date of death from any cause or the date of the last visit, whichever came first, assessed up to 60 months |
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Inclusion Criteria:
Exclusion Criteria:
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consecutive patients with resectable or borderline resectable pancreatic ductal adenocarcinoma (PDAC)
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| ID | Term |
|---|---|
| D010190 | Pancreatic Neoplasms |
| ID | Term |
|---|---|
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D004701 | Endocrine Gland Neoplasms |
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| ID | Term |
|---|---|
| D020360 | Neoadjuvant Therapy |
| ID | Term |
|---|---|
| D003131 | Combined Modality Therapy |
| D013812 | Therapeutics |
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| D004066 |
| Digestive System Diseases |
| D010182 | Pancreatic Diseases |
| D004700 | Endocrine System Diseases |