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Preeclampsia/eclampsia is part of a spectrum of multi-systemic pregnancy disorder that contributes substantially to maternal and perinatal morbidity and mortality, especially in low resource setting. This study was done in Abakaliki, Ebonyi State, Southeast Nigeria.
To compare the efficacy of loading dose of magnesium sulphate with that of the Pritchard regimen in the prevention of eclampsia in severe preeclampsia and recurrent fits in eclampsia in a low resource setting.
A prospective, single blinded randomized controlled study of loading dose versus Pritchard regimens of MgSO4 at the Teaching Hospital Abakaliki. One hundred and twenty patients were recruited 60 to each arm using computer-generated numbers. Sociodemographic characteristics, efficacy and adverse effects of the drug on the mother and baby were noted.
Background: Preeclampsia/eclampsia is part of a spectrum of multi-systemic pregnancy disorder that contributes substantially to maternal and perinatal morbidity and mortality, especially in low resource setting. This study was done in Abakaliki, Ebonyi State, Southeast Nigeria.
Objectives: To compare the efficacy of loading dose of magnesium sulphate with that of the Pritchard regimen in the prevention of eclampsia in patients with severe preeclampsia and recurrent fits in eclampsia in a low resource setting like ours.
Methods: This was a prospective, single blinded randomized controlled study of loading dose versus Pritchard regimens of MgSO4 at Alex Ekwueme Federal University Teaching Hospital Abakaliki. One hundred and twenty patients were recruited 60 to each arm using computer-generated numbers. Social demographic characteristics, efficacy and adverse effects of the drug on the mother and baby were noted. Data were collated, tabulated and analyzed using the statistical package for social sciences (SPSS) software (version 22, Chicago II, USA)
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| first arm - Loading dose of magnesium sulfate | Active Comparator | This arm received Loading dose of magnesium sulfate only. those that developed complication in each arm were managed according to departmental protocol. |
|
| 2. Pritchard regimen | Active Comparator | This arm received the full dose of magnesium sulfate regimen by Pritchard. those that developed complication in each arm were managed according to departmental protocol also. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Use of magnesium sulfate to prevent and stop fits in pre-eclampsia and Eclampsia | Drug | Loading dose magnesium sulfate versus the Pritchard regimen |
|
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of convulsions | percentage of fits in severe pre-eclampsia and recurrence of fits in eclampsia | During the intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Drug toxicity | number of neonatal asphyxia, respiratory depression, loss of tendon reflex and cardiac arrest. | During the intervention |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Federal Teaching Hospital, Abakaliki | Abakaliki | Ebonyi State | 480001 | Nigeria |
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Prevention of Eclampsia in severe pre-eclampsia and further fits in Eclampsia.
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| ID | Term |
|---|---|
| D011225 | Pre-Eclampsia |
| D004461 | Eclampsia |
| ID | Term |
|---|---|
| D046110 | Hypertension, Pregnancy-Induced |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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