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This is a single-center study retrospectively evaluating a local clinical routine to administer norepinephrine in midline catheters, with regard to complications and patient outcomes
Se attached study protocol
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Norepinephrine | Drug | Norepinephrine administered in midline catheter according to clinical routine |
|
| Measure | Description | Time Frame |
|---|---|---|
| Proportion of patients with a major complication of norepinephrine administration in midline | extravasation of norepinephrine, midline-associated bloodstream infection, thrombosis | day 30 |
| Measure | Description | Time Frame |
|---|---|---|
| Proportion of patients with a minor complication of norepinephrine administration in midline | infiltration, occlusion of midline, dislodgement, leakage, other | day 30 |
| Proportion of patients receiving a CVC after midline |
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Inclusion Criteria:
Exclusion Criteria:
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The study population are critically ill patients in need of vasopressors, primarily with septic shock.
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| Name | Affiliation | Role |
|---|---|---|
| Gustav Torisson, PhD | Region Skane | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Skåne University Hospital | Malmö | Sweden |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39806688 | Derived | Karlsson H, Afrasiabi A, Ohlsson M, Mansson V, Hartman H, Torisson G. Treating shock with norepinephrine administered in midline catheters in an intermediary care unit: a retrospective cohort study. BMJ Open. 2024 Dec 30;14(12):e091311. doi: 10.1136/bmjopen-2024-091311. |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP | Yes | Yes | No | Study Protocol and Statistical Analysis Plan | Sep 7, 2023 | Oct 4, 2023 | Prot_SAP_000.pdf |
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| ID | Term |
|---|---|
| D012772 | Shock, Septic |
| D007022 | Hypotension |
| D012769 | Shock |
| D013927 | Thrombosis |
| ID | Term |
|---|---|
| D018805 | Sepsis |
| D007239 | Infections |
| D018746 | Systemic Inflammatory Response Syndrome |
| D007249 | Inflammation |
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| ID | Term |
|---|---|
| D009638 | Norepinephrine |
| D014662 | Vasoconstrictor Agents |
| ID | Term |
|---|---|
| D004983 | Ethanolamines |
| D000605 | Amino Alcohols |
| D000438 | Alcohols |
| D009930 | Organic Chemicals |
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Has the patient received central line after midline placement
| day 30 |
| Proportion of patients with different intermediary care unit outcomes | Where did the patient go after intermediary care? discharged / escalated to the ICU / deceased | day 30 |
| D010335 |
| Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D016769 | Embolism and Thrombosis |
| D000588 |
| Amines |
| D015306 | Biogenic Monoamines |
| D001679 | Biogenic Amines |
| D002395 | Catecholamines |
| D002396 | Catechols |
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D002317 | Cardiovascular Agents |
| D045506 | Therapeutic Uses |
| D020228 | Pharmacologic Actions |
| D020164 | Chemical Actions and Uses |