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The goal of this clinical trial is to investigate the effects of yoga participation for adults with cystic fibrosis.
The main question it aims to answer is: does participation in yoga affect health-related quality of life for adults with cystic fibrosis?
Researchers will compare a group completing a 12-week yoga programme alongside usual cystic fibrosis care, to a group completing usual care alone to see if the addition of yoga effects health-related quality of life.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Yoga intervention group | Active Comparator | 12 week programme of yoga - encouraged to complete 1 live class and one pre-recorded class a week. Participants will continue with usual cystic fibrosis care. |
|
| Control group | No Intervention | Usual cystic fibrosis care. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Yoga | Other | Yoga classes |
|
| Measure | Description | Time Frame |
|---|---|---|
| Respiratory Health- related quality of life - measured by the respiratory domain of the Cystic Fibrosis Questionnaire - Revised. | Cystic Fibrosis Questionnaire - Revised (CFQ-R) respiratory domain.Scores range from 0 to 100, with higher scores indicating better health. | Baseline, 12 and 24-weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Other Health-related quality of life domains - captured on the Cystic Fibrosis Questionnaire - Revised (CFQ-R) | Cystic Fibrosis Questionnaire - Revised (CFQ-R) other eleven domains. Scores range from 0 to 100, with higher scores indicating better health. | Baseline, 12 and 24-weeks |
| One Minute Sit to Stand Test |
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Inclusion Criteria:
Diagnosis of CF (confirmed by standard criteria; (Farrell et al. 2017))
Sixteen years of age or over
Home internet access
Ability to complete questionnaires in English
Stable CF disease as judged by the investigator, a senior CF clinician
Exclusion Criteria:
Inability to consent for treatment or measurement
Current participation in another interventional study of a medicinal product
Current haemoptysis (greater than streaking in the sputum)
Known pregnancy at time of recruitment
Forced expiratory volume in 1 second (FEV1) below 30% predicted at baseline
Use of ambulatory oxygen therapy, long-term oxygen therapy (LTOT) or non-invasive ventilation
Current regular participation in yoga practice
Current neurological or musculoskeletal injury which would prevent completion of yoga
Diagnosis of osteoporosis (bone density Z score <-2.5) or history of spontaneous spinal fractures
Uncontrolled gastroesophageal reflux
Acute pulmonary exacerbation within 28 days of screening
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| Name | Affiliation | Role |
|---|---|---|
| Nicholas Simmonds | Royal Brompton Hospital, Guys and St Thomas's Foundation Trust | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The Royal Brompton Hospital | London | Greater London | SW3 6NP | United Kingdom |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41494700 | Derived | Stanford GE, Scarborough P, Charman SC, Cameron RA, Wagner AP, Simmonds NJ. Yoga Outcomes Get Assessed in Cystic Fibrosis (YOGA-CF): protocol of a multicentre interventional randomised controlled clinical trial-investigating effects of a 12-week yoga intervention for adults with cystic fibrosis. BMJ Open Respir Res. 2026 Jan 6;13(1):e003405. doi: 10.1136/bmjresp-2025-003405. |
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| ID | Term |
|---|---|
| D003550 | Cystic Fibrosis |
| ID | Term |
|---|---|
| D010182 | Pancreatic Diseases |
| D004066 | Digestive System Diseases |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
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| ID | Term |
|---|---|
| D015013 | Yoga |
| ID | Term |
|---|---|
| D026441 | Mind-Body Therapies |
| D000529 | Complementary Therapies |
| D013812 | Therapeutics |
| D026443 | Spiritual Therapies |
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Participant stands up and sits down from a chair for one minute and the number of completed sit-to-stands is recorded. |
| Baseline, 12 and 24-weeks |
| Forced Expiratory Volume in 1 second | Forced expiratory volume in 1 second (FEV1) obtained through spirometry. Measured in litres and percentage predicted (using Global Lung Index equations) | Baseline, 12 and 24-weeks |
| Forced vital capacity (FVC) | Forced vital capacity obtained through spirometry. Measured in litres and percentage predicted (using Global Lung Index equations) | Baseline, 12 and 24-weeks |
| D030342 |
| Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D007232 | Infant, Newborn, Diseases |
| D026241 |
| Exercise Movement Techniques |
| D026741 | Physical Therapy Modalities |