A comprehensive perioperative nutrition management plan for pancreaticoduodenectomy, primarily based on pancreatic enzyme replacement therapy (PERT). A prospective randomized controlled study was conducted to comprehensively analyze the perioperative nutritional status of patients undergoing pancreaticoduodenectomy, with the aim of exploring:

1. The effect of PERT on postoperative complications and physiological status after pancreaticoduodenectomy;
2. The efficacy of PERT treatment on clinical symptoms, nutritional indicators, and quality of life (QOL) related to pancreatic exocrine dysfunction (PEI) after pancreaticoduodenectomy;
3. The personalized full process nutrition management strategies based on risk factor stratification.

Inclusion Criteria:

• Gender unlimited, 18-80 years old;
• Patients undergoing pancreaticoduodenectomy due to various benign or malignant diseases;
• Voluntary testing with informed consent.

Exclusion Criteria:

• Pregnant women and lactating women
• Patients with distant metastasis based on tumor staging before surgery;
• Tumor recurrence;
• Refuse to sign the consent form.