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Recently, more and more total pancreatectomy (TP) has been performed for pancreatic ductal cell adenocarcinoma (PDCA) which abuts or involves both gastroduodenal and splenic arteries. Warshaw's procedure (spleen-preserving distal pancreatectomy with excision of splenic vessels) has been safely performed for years. Likewise, both pancreatic tail and spleen can be preserved after excision of splenic vessels for leftward extension of pancreatic parenchyma transaction line during Whipple (WOTSA). In that case, TP can be replaced by WOTSA. This uncontrolled before and after study assesses the safety and efficacy of a new technique "Whipple over the splenic artery (WOTSA)" as a treatment for PDAC which traditionally requires total pancreatectomy (TP).
Recently, more and more total pancreatectomy (TP) has been performed for pancreatic ductal cell adenocarcinoma (PDCA) which abuts or involves both gastroduodenal and splenic arteries. Warshaw's procedure (spleen-preserving distal pancreatectomy with excision of splenic vessels) has been safely performed for years. Likewise, both pancreatic tail and spleen can be preserved after excision of splenic vessels for leftward extension of pancreatic parenchyma transaction line during Whipple (WOTSA). In that case, TP can be replaced by WOTSA. This uncontrolled before and after study assesses the safety and efficacy of a new technique "Whipple over the splenic artery (WOTSA)" as a treatment for PDAC which traditionally requires total pancreatectomy (TP).
Methods: The study group comprised 40 consecutive patients who underwent WOTSA for PDAC. Their clinicopathological characteristics and survival were compared with those of a historical control group comprising 30 consecutive patients who underwent TP between.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Study | Patients who underwent Whipple over the splenic artery (WOTSA) as a treatment for PDAC |
| |
| Control | Patients who underwent total pancreatectomy (TP) as a treatment for PDAC |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Whipple over the splenic artery | Procedure | Treatment for pancreatic ductal cell adenocarcinoma |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Clinicopathological characteristics | Measurement of the remnant pancreatic volume | before |
| Clinicopathological characteristics | Measurement of the remnant pancreatic volume | 1 week after the operation |
| Measure | Description | Time Frame |
|---|---|---|
| Postoperative chemotherapy and follow-up | Measurement of the remnant pancreatic volume and physiological parameters | 1 month after the operation |
| Measure | Description | Time Frame |
|---|---|---|
| Number of participants with treatment-related adverse events as assessed by CTCAE v4.0 | Measurement of the physiological parameters | 1 day before the operation |
| Number of participants with treatment-related adverse events as assessed by CTCAE v4.0 |
Inclusion Criteria:
Exclusion Criteria:
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pancreatic ductal cell adenocarcinoma (PDCA) patients
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ting-Chun Kuo | Contact | +88623123456 | 62557 | tinakuo1204@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| National Taiwan University Hospital | Recruiting | Taipei | Taiwan |
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| Total pancreatectomy |
| Procedure |
Treatment for pancreatic ductal cell adenocarcinoma |
|
Measurement of the physiological parameters
| 3 months after the operation |
| Number of participants with treatment-related adverse events as assessed by CTCAE v4.0 | Measurement of the physiological parameters | 6 months after the operation |