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To detect the expression of AUNIP in cervical cancer serum, and to clarify its diagnostic and prognostic value.
Blood of all study participants of cervical cancer patients are collected to detect the expression of AUNIP, analyze the statistical correlation between the expression of cervical cancer AUNIP and clinicopathological parameters of patients, and preliminarily understand the expression of AUNIP in cervical cancer tumor tissues and its clinical diagnostic and progniostic value.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| study group | Women aged 20-60; There is a definite pathological diagnosis of cervical cancer |
| |
| Healthy control group | Women aged 20-60; No tumors in the uterus or other parts of the body; No inflammatory disease; Blood routine and blood biochemical tests are normal. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Detection of serum AUNIP expression | Diagnostic Test | The experiment is carried out according to the ELISA kit instructions, and the absorbance optic density (OD) value of the enzyme labeler at 450 nm is read. The protein concentration of AUNIP in the serum sample is calculated according to the standard curve. |
| Measure | Description | Time Frame |
|---|---|---|
| AUNIP expression in serum | Serum AUNIP expression is detected by ELISA kit. The results will be recorded seperately. | through study completion, an average of 3 year |
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Inclusion Criteria:
Study group inclusion criteria:
Healthy control group:
Exclusion Criteria:
Exclusion criteria of the study group:
Exclusion criteria of healthy control group:
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In this study, 150 patients with cervical cancer in the First Affiliated Hospital of Shandong First Medical University (Shandong Qianfoshan Hospital) are selected as the study group. 150 healthy women are taken as control group during the same period.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Lin Yuan, Ph.D. | Contact | 0531-89269678 | yuanl@sdfmu.edu.cn |
| Name | Affiliation | Role |
|---|---|---|
| Lin Yuan, Ph.D. | Qianfoshan Hospital | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31409573 | Background | Yang Z, Liang X, Fu Y, Liu Y, Zheng L, Liu F, Li T, Yin X, Qiao X, Xu X. Identification of AUNIP as a candidate diagnostic and prognostic biomarker for oral squamous cell carcinoma. EBioMedicine. 2019 Sep;47:44-57. doi: 10.1016/j.ebiom.2019.08.013. Epub 2019 Aug 10. | |
| 33363020 | Background | Ma C, Kang W, Yu L, Yang Z, Ding T. AUNIP Expression Is Correlated With Immune Infiltration and Is a Candidate Diagnostic and Prognostic Biomarker for Hepatocellular Carcinoma and Lung Adenocarcinoma. Front Oncol. 2020 Dec 9;10:590006. doi: 10.3389/fonc.2020.590006. eCollection 2020. |
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The plan will be shared after the clinial trial is completed and the patent protection is obtained.
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| ID | Term |
|---|---|
| D002583 | Uterine Cervical Neoplasms |
| ID | Term |
|---|---|
| D014594 | Uterine Neoplasms |
| D005833 | Genital Neoplasms, Female |
| D014565 | Urogenital Neoplasms |
| D009371 | Neoplasms by Site |
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|
| D009369 |
| Neoplasms |
| D002577 | Uterine Cervical Diseases |
| D014591 | Uterine Diseases |
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D000091662 | Genital Diseases |