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| ID | Type | Description | Link |
|---|---|---|---|
| NCI-2023-04797 | Registry Identifier | CTRP (Clinical Trial Reporting Program) | |
| 23-001388 | Other Identifier | Mayo Clinic Institutional Review Board |
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This study explores how microorganisms in the gut can affect the growth and progression of brain tumors.
PRIMARY OBJECTIVES:
I. To establish a Mayo Clinic Florida Brain Tumor-Gut Axis Human Biorepository by sequential collection of fecal, urine, blood, saliva, and/or tissue samples and clinical patient information.
II. To use spatial transcriptome/proteomics/multi-omics coupled with microbiome data from various sources including brain tissue and stool samples to understand how microbiota could impact disease development, progression, and treatment response in patients with brain cancer.
III. To study the effect of microbiome and potential relationships and/or microbiome reconstruction to impact patient's clinical outcomes including chemo, radiation, immunotherapy and/or cellular therapy.
OUTLINE: This is an observational study.
Participants undergo blood, tissue, saliva, urine and stool sample collection and complete questionnaires on study.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Observational | Participants undergo blood, tissue, saliva, urine and stool sample collection and complete questionnaires on study. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Non-Interventional Study | Other | Non-interventional study |
|
| Measure | Description | Time Frame |
|---|---|---|
| Establish the Mayo Clinic Florida Tumor-Gut Axis Biorepository | Biological samples such as stool, urine, blood, saliva, and/or tissue will be collected for storage in the Tumor-Gut Axis Biorepository. Samples may be collected at any of the following time periods during study participation: before/after steroid therapy, before/after surgical intervention, before/after radiation therapy, and before/after chemotherapy. | Approximately 1 year, or until samples have been collected based on scheduled treatment. |
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Inclusion Criteria:
Exclusion Criteria:
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All patients undergoing resection for a tumor of the central nervous system and associated controls are eligible to participate in this study.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Clinical Trials Referral Office | Contact | 855-776-0015 | mayocliniccancerstudies@mayo.edu |
| Name | Affiliation | Role |
|---|---|---|
| Alfredo Quinones-Hinojosa, M.D. | Mayo Clinic | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mayo Clinic in Florida | Recruiting | Jacksonville | Florida | 32224-9980 | United States |
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| Label | URL |
|---|---|
| Mayo Clinic Clinical Trials | View source |
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| ID | Term |
|---|---|
| D016543 | Central Nervous System Neoplasms |
| ID | Term |
|---|---|
| D009423 | Nervous System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D009422 | Nervous System Diseases |
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Samples stored for future research if participant gives permission.