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| Name | Class |
|---|---|
| Hellenic Stroke Organization | UNKNOWN |
| Municipality of North Kynouria | UNKNOWN |
| Greece 2021 Committee | OTHER_GOV |
| Astros Health Care Center |
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The North Kynouria Project was initiated to study cardiovascular/stroke risk factors by employing mass screening and long-term surveillance of an adult population in the municipality of North Kynouria, in the county of Arcadia, Peloponnese, Greece. The North Kynouria Study was initiated to assess modifiable and non-modifiable determinants of cerebrovascular and coronary heart disease.
BACKGROUND:
The North Kynouria Project is a longitudinal, interventional-behavioural, prospective study aiming to identify cardiovascular/stroke risk factors, in the adult population of the municipality of North Kynouria, in the county of Arcadia, Peloponnese, Greece. The project, initiated in November 2022, recruits volunteers, of both sexes, over 18 years of age, irrespective of their personal history of cardiovascular disease. The epidemiology and burden of cardiovascular disease in North Kynouria remain unknown. The study aims to explore and document the prevalence of major cardiovascular/stroke risk factors, as well as the nutritional status, cigarette smoking, exercise habits, alcohol consumption, and overall quality of life of the inhabitants.
DESIGN NARRATIVE:
The screening exam is conducted at the Astros, Health Center, by obtaining the patient's personal history, and information about the patient's habits, such as physical activity, smoking, and alcohol consumption. Body weight, height, and waist-to-hip ratio are also measured. During the examination, blood pressure is evaluated using a pre-specified protocol, including assessment of orthostatic hypertension. Further testing includes electrocardiography, ankle-brachial index, direct ophthalmoscopy, and carotid and cardiac ultrasound. Blood samples are collected and stored at the deep freeze of the Astros premises, and blood count, lipid panel, and liver and kidney function are measured.
The main field of interest is the prevalence and burden of risk factors and cardiovascular disease in the wider region of North Kynouria, Arcadia Greece. The project aims to assess the epidemiology of CVD and consequently improve public health and engage with the local community through healthy behavioral education.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patient screening | Experimental | Single group, no masking, receiving the intervention |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Patient counselling | Behavioral | Patient counseling, lifestyle modifications, medication evaluation, and adherence |
|
| Measure | Description | Time Frame |
|---|---|---|
| Major adverse cardiovascular events | myocardial infarction, ischemic and hemorrhagic stroke | up to 5 years after enrollment |
| All-cause mortality | Death by any cause, cardiovascular, infection, cancer, other | up to 5 years after enrollment |
| Hospitalizations | Any cause hospitalization | up to 5 years after enrollment |
| Emergency room visits | Any cause of emergency room visit | up to 5 years after enrollment |
| Measure | Description | Time Frame |
|---|---|---|
| New diagnosis of Arterial hypertension | Any diagnosis of arterial hypertension, masked, white-coat, nocturnal | up to 1 year after enrollment |
| New diagnosis of diabetes mellitus | Type 1 or Type 2 |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Charalampos Milionis, MD, PhD | Contact | hmilioni@uoi.gr | ||
| George Ntaios, MD, PhD | Contact | 6972770288 | gntaios@med.uth.gr |
| Name | Affiliation | Role |
|---|---|---|
| Charalampos Milionis, MD, PhD | University of Ioannina | Principal Investigator |
| George Ntaios, MD, MSc, PhD | University of Thessaly | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Astros Health Care Center | Recruiting | Ástros | 220 01 | Greece |
Study protocol details
2024-2025
Through access granting from the University of Ioannina
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| ID | Term |
|---|---|
| D002318 | Cardiovascular Diseases |
| D006331 | Heart Diseases |
| D002561 | Cerebrovascular Disorders |
| D003327 | Coronary Disease |
| D050171 | Dyslipidemias |
| D020521 | Stroke |
| D009203 | Myocardial Infarction |
| D006973 | Hypertension |
| D003920 | Diabetes Mellitus |
| D058729 | Peripheral Arterial Disease |
| D050197 | Atherosclerosis |
| D014652 | Vascular Diseases |
| D001157 | Arterial Occlusive Diseases |
| ID | Term |
|---|---|
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D017202 | Myocardial Ischemia |
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| UNKNOWN |
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| up to 1 year after enrollment |
| New diagnosis of dyslipidemia | New diagnosis or uncontrolled | up to 1 year after enrollment |
| New diagnosis of carotid atherosclerosis | Evaluation of carotid artery stenosis | up to 1 year after enrollment |
| New diagnosis of peripheral artery disease | Ankle Brachial Index evaluation | up to 1 year after enrollment |
| D052439 | Lipid Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D007238 | Infarction |
| D007511 | Ischemia |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009336 | Necrosis |
| D044882 | Glucose Metabolism Disorders |
| D004700 | Endocrine System Diseases |
| D001161 | Arteriosclerosis |
| D016491 | Peripheral Vascular Diseases |