assessment of brain atrophy associated with septic ICU patients by using MSCT Volumetry

Sepsis is the leading cause of admission to ICU , the number of patients who survive and discharge from ICU has also increased due to technological advances in ICU however quality of life of these patients after ICU discharge is lower than that of healthy people of a similar age, in particular Sepsis associated encephalopathy associated with brain dysfunction.

We hypothesized that brain damage including brain volume reduction that ocurre in acute phase of Sepsis using CT scan and there finding " relationship to risk factor and outcome".

We compared head CT finding at time of admission with those obtained during the course of the treatment

Inclusion Criteria:

• patients >16years old with sepsis associated with disturbance in conscious level admitted to ICU

Exclusion Criteria:

• Age< 16y Brain death Hematological disease Malignant disease Hypoxemia Error in automatic tissue classification Motion artifac

All the patients will be included within ehs inclusion criteria after giving informed consent from patients or from the hospital board to review patients' medical records, it will include:

• Full history taking.
• Clinically provisinal diagnosis .
• Blood and bacterial culture was performed at the time of admission for all patients .
• Firstly All studies were performed by using a CT device. CT scans measuring brain volume using BCR which is the width between anterior horn of the bilateral lateral ventricle divided by that of the cerebrum at the same height at the caudate nucleus that measuring in particular frontal lobe volume .
• Also using Evan index which is the width between anterior horn of the bilateral lateral ventricles divided by cranial lumen at the same height .
• When increase BCR and EI ,decrease in brain volume ocurr.