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This is an observational study of patients diagnosed with pancreatic cancer by pathology, with a control group of patients with pathology suggestive of benign pancreatic lesions and normal subjects, and the diagnostic ability of exosomes to identify patients with pancreatic cancer was assessed through the detection of exosomes in the peripheral blood.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| pancreatic patients | Cases will be the patients with newly-diagnosed pancreatic. | ||
| The controls | Controls will be selected from patients with pancreatitis from the same hospital as the case, matched by gender, race and age (1:1). |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Other |
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| Measure | Description | Time Frame |
|---|---|---|
| Characterization of proteins in tumor exosomes from patients with pancreatic cancer | We will select specific protein A from circulating exosomes of pancreatic cancer patients for further analysis. | Up to 2 years from start of study |
| The expression of protein A in the circulating exosomes from patients | By detecting the expression of protein A in circulating exosomes of patients. the ROC curve of A+ circulating exosomes will be compared to clinical standard tumor biomarkers (e.g., CA199) in pancreatic cancer patients. | Up to 2 years from start of study |
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Inclusion Criteria:
Diagnosis of pancreatic cancer confirmed by imaging (case) Diagnosis of chronic pancreatitis confirmed by imaging (hospital control)
Exclusion Criteria:
The pathology diagnosis and imaging does not matched Patients with other malignant tumors Patients with other severe systemic diseases
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Cases will be patients with newly diagnosed pancreatic cancer. Controls will be selected from patients with pancreatitis in the same hospital as the cases, matched by sex, race and age (1:1). A total of 400 patients with gallbladder cancer will be recruited.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Xinhua Hospital, Affiliated to Shanghai Jiao Tong University, School of Medicine | Shanghai | Shanghai Municipality | 20092 | China |
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Serum