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Over 50% of the Veterans enrolled for VA health care are over the age of 65. Dementia prevalence increases with age, and with the increase in the population of people ages 65 and older, the total number of people with dementia is also increasing. Older Veterans often have comorbid PTSD, major depression and traumatic brain injury so that they are at 2 to 5 times the risk for cognitive impairment and dementia compared to the general population. There is evidence that exercise interventions in sedentary older adults could improve both physical and cognitive function. However, there have been very few studies on the effects of exercise on cognition in older Veterans and do not reflect the broader ethnic and health-status diversity of Veterans. Thus, improved knowledge of the role of exercise on cognition as well as the predictive power of biomarkers could have a major beneficial impact on Veterans' functional independence and quality of life. The investigators hypothesize that participation in the VA Gerofit exercise program will improve cognitive function in older Veterans and that blood and muscle biomarkers will predict these improvements.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Gerofit exercise | Active Comparator | Participants enrolled in the Gerofit program |
|
| Health education | Placebo Comparator | Participants enrolled in monthly in-person health education sessions which do not include a physical activity/exercise promotion session |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Gerofit exercise | Behavioral | Individualized exercise prescription as well as a group exercise class based on physical function assessments offered 3x/week |
|
| Measure | Description | Time Frame |
|---|---|---|
| Memory composite score | HVLT-R, verbal memory and BVMT-R, visual memory | Change from baseline at 3 months |
| Executive Function composite score | Stroop C, Trails B, Digit span backwards and sequencing from WAIS-IV, verbal fluency, FAS and animals | Change from baseline at 3 months |
| Total BDNF | Total brain derived neurotrophic factor (BDNF) concentrations in serum | Change from baseline at 3 months |
| Mature BDNF | Mature brain derived neurotrophic factor (BDNF) concentrations in serum | Change from baseline at 3 months |
| Memory composite score | HVLT-R, verbal memory and BVMT-R, visual memory | Change from baseline at 12 months |
| Executive Function composite score | Stroop C, Trails B, Digit span backwards and sequencing from WAIS-IV, verbal fluency, FAS and animals | Change from baseline at 12 months |
| Total BDNF | Total brain derived neurotrophic factor (BDNF) concentrations in serum | Change from baseline at 12 months |
| Mature BDNF | Mature brain derived neurotrophic factor (BDNF) concentrations in serum |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Cathy C Lee, MD | Contact | (310) 268-4110 | cathy.lee2@va.gov |
| Name | Affiliation | Role |
|---|---|---|
| Cathy C Lee, MD | VA Greater Los Angeles Healthcare System, West Los Angeles, CA | Principal Investigator |
| Jonathan M Wanagat, MD PhD | VA Greater Los Angeles Healthcare System, West Los Angeles, CA | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| VA Greater Los Angeles Healthcare System, West Los Angeles, CA | Recruiting | West Los Angeles | California | 90073-1003 | United States |
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| ID | Term |
|---|---|
| D060825 | Cognitive Dysfunction |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D001519 | Behavior |
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randomized controlled study
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Gerofit intervention vs Health Education Control
| Health education | Behavioral | Scheduled monthly in-person health education discussion sessions covering 12 different health topics not including a physical activity/exercise promotion session |
|
| Change from baseline at 12 months |
| Stacy Wilkins, PhD | VA Greater Los Angeles Healthcare System, West Los Angeles, CA | Principal Investigator |
| Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD | Recruiting | Baltimore | Maryland | 21201 | United States |
|