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| ID | Type | Description | Link |
|---|---|---|---|
| 2023-A01452-43 | Other Identifier | ANSM |
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Cardiac readaptation aims to mitigate cardiovascular risks and enhance the quality of life among coronary patients. Our research laboratory has an international expertise in training optimization in top-athletes and a previous study has demonstrated the efficacy of optimizing cardiac rehabilitation through the power-force-velocity profile (PFVP). The findings exhibited significant improvements in aerobic capacity, muscular strength, and cardiovascular parameters among patients who were trained based on their PFVP. Guided training utilizing heart rate variability (HRV) is also garnering increasing interest as a means to optimize training load and promote recovery
Our study aims to evaluate the application of HRV in regulating training load based on fatigue levels in cardiac rehabilitation patients utilizing the PFVP framework.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Experimental group | Experimental | Patient with acute coronary syndrome will be included. According to their initial strength-speed profile, coronary patients will benefit from an individualized cardiac rehabilitation program, with strength or speed training adapted to the autonomic nervous system (ANS). |
|
| Control group | Active Comparator | Patient with acute coronary syndrome will be included. According to their initial force-velocity profile, coronary patients will have an individualized cardiac rehabilitation program, either with a training in force or in velocity. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| training strategy with adaptation of training strategies to the ANS | Other | a training strategy for subjects whose PFVP is in favour of strength or speed with training load adjusted according to SNA |
| Measure | Description | Time Frame |
|---|---|---|
| The root mean square of successive differences in heart rate or RMSSD | The root mean square of successive differences in heart rate or RMSSD will be measured from a nocturnal Holter ECG recording at the end of 8 weeks of exercise retraining and compared with the initial pre-training value. weeks of exercise re-training and compared with the initial pre-training value. | Baseline to 2 months |
| Measure | Description | Time Frame |
|---|---|---|
| Value of maximum oxygen consumption | VO2 max (ml/min/kg) thanks to 24-hour ECG recording | Baseline to 2 months |
| Assessment of the ANS sympathetic branch | Assessment of the ANS sympathetic branch thanks to SDNN index value |
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Inclusion Criteria:
Exclusion Criteria:
- Significant co-morbidities limited practice of physical activity
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| David HUPIN, MD | Contact | (0)4 77 82 84 13 | +33 | David.Hupin@chu-st-etienne.fr |
| Hélène RAINGARD, CRA | Contact | (0)4.77.82.97.03 | +33 | helene.raingard@chu-st-etienne.fr |
| Name | Affiliation | Role |
|---|---|---|
| David HUPIN, MD | Centre Hospitalier Universitaire de Saint Etienne | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chu Saint-Etienne | Recruiting | Saint-Etienne | France |
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| training strategy (standard practice) | Other | a training strategy for subjects whose PFVP is in favour of strength or speed |
|
| Baseline to 2 months |
| Assessment of the ANS parasympathetic branch | Assessment of the ANS parasympathetic branch thanks to RMSSSD index value | Baseline to 2 months |
| non-invasive measurement of arterial stiffness | value of pulse wave propagation velocity | Baseline to 2 months |
| measurement of upper and lower limb muscle strength | it's a composite outcome :
| Baseline to 2 months |
| assessment of PFVP evolution | assessment of PFVP evolution thaks to cycloergometer sprint (Monark, Vansbro) | Baseline to 2 months |
| assessment of physical a activity and sedentary behavior | it's a composite outcome :
| Baseline to 2 months |
| quality of life assessment | it's a composite outcome :
| Baseline to 2 months |
| assessment of subjective fatigue | assessment of subjective fatigue thanks to FACIT-F questionary | Baseline to 2 months |
| biological data | it's a composite outcome : complete blood biology and relevant inflammatory biomarkers involved in cardiac rehabilitation. | Baseline to 2 months |
| ID | Term |
|---|---|
| D054058 | Acute Coronary Syndrome |
| D009043 | Motor Activity |
| D003324 | Coronary Artery Disease |
| ID | Term |
|---|---|
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D014652 | Vascular Diseases |
| D001519 | Behavior |
| D003327 | Coronary Disease |
| D001161 | Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
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