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Acute liver injury (ALI) is defined as an acute derangement in liver function tests associated with liver-related coagulopathy, in the absence of underlying chronic liver disease.
A subset progress to acute liver failure ,Acute liver failure represent a more severe liver injury results in hepatic encephalopathy
Acute liver injury is associated with a spectrum of haemostatic changes, including thrombocytopenia and reduced platelet function, reduced plasma levels of many coagulation factors such as factor (F)VII and increased levels of FVIII .
Pneumonia is an acute inflammation of the lower respiratory tract. Lower respiratory tract infection is a major cause of mortality worldwide .Pneumonia is most common at the extremes of life.
In adults, pneumonia can be broadly classified, on the basis of chest radiographic appearance, into lobar pneumonia, bronchopneumonia and pneumonia producing an interstitial pattern.
There is lack of data regarding outcome and hospital stay in patients with pneumonia who develop acute liver injury.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group A | About 88 patients having pneumonia and developed acute liver injury That need observation of the outcome and hospital stay to evaluate acute liver injury impact |
| |
| Group B | About 88 patients having pneumonia but did not develop acute liver injury that need observation of the outcome and hospital stay |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Acute Liver Injury | Other | To evaluate the impact of acute liver injury in patients with pneumonia on hospital stay and outcome. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Impact of Acute liver injury due to Pneumonia | Analysis the impact of acute liver injury related to patients with pneumonia on hospital stay (measured by days spent in the hospital). | From Hospital admission date to Two Months |
| Measure | Description | Time Frame |
|---|---|---|
| Patients with Pneumonia only | To evaluate the Patients with Pneumonia either developed acute liver injury or not, On Hospital Stay | From Hospital admission date to Two Months |
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Inclusion Criteria:
Exclusion Criteria:
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patients with pneumonia in hospital ward or critical care
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Beshoy Yousef, MSc | Contact | 01114761284 | Beshoyyoussef18@gmail.com | |
| Zain Elabdeen Ahmed, Professor | Contact | 01115596820 | drzain73@yahoo.com |
| Name | Affiliation | Role |
|---|---|---|
| Zain Elabdeen Ahmed, Professor | Assuit Faculty of Medicine | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty Of Medicine | Asyut | Egypt |
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| ID | Term |
|---|---|
| D011014 | Pneumonia |
| D000086382 | COVID-19 |
| ID | Term |
|---|---|
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
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| D011024 |
| Pneumonia, Viral |
| D014777 | Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |