The goal of this study is to evaluate the capacity of allogenic mesenchymal stromal cells form bone marrow (BM-MSC) or adipose tissue(Ad-MSC) to induce wound healing in patients with burn wounds.

Based on the paracrine and immunomodulatory effects of MSCs, they are considered promising cells for tissue engineering and skin regeneration in burn wounds. This protocol is designed to evaluate the efficacy of transplantation of allogenic BM-MSCs or Ad-MSCs, included in preclotted platelet-rich plasma (PRP), in patients with deep- or full-thickness burns (second- or third-degree / AB B or B degree). All patients will receive concomitant first-line treatments.

Inclusion Criteria:

• Age between 2 weeks and 85 years old
• Patient with second- or third-degree burn (AB/B or B).
• Thermal burns
• Electrical burns
• Chemical burns
• Informed consent of the patient or caretaker

Exclusion Criteria:

• First degree burn (A or AB)
• Evidence of active infection at the wound site
• Chronic malnutrition
• Systemic inflammatory response syndrome (SIRS) or sepsis
• Moderate or severe respiratory tract or lungs burn injuries
• Autoimmune disease (e.g. multiple sclerosis, lupus erythematosus)
• Severe pulmonary disease, hematologic disease, malignancy, or hypo-immunity.
• Diabetes
• Pregnancy