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| Name | Class |
|---|---|
| University of Copenhagen | OTHER |
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Coronary computed tomography angiography (CCTA) is a widely accepted initial diagnostic test for individuals suspected of having chronic coronary syndromes. However, there is limited evidence supporting its use in the acute setting. So far, no large-scale randomized trial has examined the performance of CCTA as an alternative to invasive coronary angiography (ICA) in individuals with non-ST-segment elevation myocardial infarction (NSTEACS).
If CCTA were to replace ICA as a routine procedure for individuals with NSTEACS, it could reduce the risk of complications related to ICA, improve patient comfort, expedite decision-making, and reduce healthcare expenses and interhospital transfers.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Coronary computed tomography angiography + team-based interventional triage | Active Comparator |
| |
| Conventional invasive coronary angiography | Other |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| CCTA | Procedure | Participants will be examined with CCTA during admission. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Number of participants with a combined endpoint of major adverse cardiac events | All-cause mortality, non-fatal myocardial infarction, hospitalization with refractory angina, or hospitalization with heart failure. | At 1 year. |
| Measure | Description | Time Frame |
|---|---|---|
| Number of participants with a the individual composites of the primary outcome | All-cause mortality, non-fatal myocardial infarction, hospitalization with refractory angina, or hospitalization with heart failure. | At 1 year. |
| Number of participants with cardiovascular death |
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Inclusion criteria:
Exclusion criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Niels Thue Olsen, PhD | Contact | +45 38 68 38 68 | niels.thue.olsen@regionh.dk |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Herlev and Gentofte Hospital | Recruiting | Copenhagen | Hellerup | 2900 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41360328 | Derived | Sorgaard MH, Kristensen AT, Eskesen K, Kofoed KF, Linde JJ, Kelbaek H, Ottesen M, Neland K, Kragelund C, Bertelsen MLN, Hove JD, Mork G, Kristiansen OP, Engstrom T, Lonborg JT, Kuhl JT, Risom SS, Blanche P, Olsen NT. Coronary computed tomography angiography versus invasive coronary angiography for interventional triage in acute coronary syndrome: Design of the randomized TRACTION trial. Am Heart J. 2026 Apr;294:107325. doi: 10.1016/j.ahj.2025.107325. Epub 2025 Dec 6. |
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Data will be shared upon reasonable request and uploaded to a repository after the trial has been concluded.
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| SAP | No | Yes | No | Statistical Analysis Plan | Oct 16, 2024 | Feb 14, 2025 |
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| Conventional ICA | Procedure | Patients will be examined with conventional standard-of-care ICA. |
|
| Team-based interventional triage | Other | The CCTA will be discussed at a coronary CT-team conference to establish the treatment strategy and provide guidance for any necessary interventional procedure. |
|
| At 1 year. |
| Number of participants with unplanned coronary revascularization | At 1 year. |
| Health-related Quality of life | Measured by EQ-5D-5L | At 1 year. |
| Angina symptom burden | Measured by Seattle Angina Questionnaire | At 1 year. |
| Total (cumulative) radiation dosage during index admission | At 1st hospital discharge, an average of 2 days. |
| Length of index hospitalization | At 1st hospital discharge, an average of 2 days. |
| Bispebjerg Hospital | Recruiting | Bispebjerg | Denmark |
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| Rigshospitalet | Recruiting | Copenhagen | Denmark |
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| Zealand University Hospital | Recruiting | Copenhagen | Denmark |
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| North Zealand Hospital | Recruiting | Hillerød | Denmark |
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| Hvidovre Hospital | Recruiting | Hvidovre | Denmark |
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| SAP_000.pdf |
| ID | Term |
|---|---|
| D017202 | Myocardial Ischemia |
| D000072658 | Non-ST Elevated Myocardial Infarction |
| D000789 | Angina, Unstable |
| D003327 | Coronary Disease |
| D009203 | Myocardial Infarction |
| D023921 | Coronary Stenosis |
| D003324 | Coronary Artery Disease |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D014652 | Vascular Diseases |
| D007238 | Infarction |
| D007511 | Ischemia |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009336 | Necrosis |
| D000787 | Angina Pectoris |
| D002637 | Chest Pain |
| D010146 | Pain |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D001161 | Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
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