This trial assessed the efficacy of potassium competetor acid blocker (P-CAB) in the eradication of H.pylori

The aim of this study is to compare the effectiveness of Vonaprazan based therapy vs.Proton Pump Inhibitor (PPI)based therapy for the eradication of H.Pylori infection in treatment naive and treatment experienced Egyptian patients.This prospective, non- randomized, controlled study was conducted on symptomatic patients admitted at Tropical Medicine Department at Ain Shams University Hospitals and those presenting at outpatient clinic. The study was conducted in the period from the 1st of January 2022 to the 1st of June 2023.

Inclusion Criteria:

• Age above 18 years of both genders.
• Symptomatic patients who has been diagnosed to be H. pylori positive stool by using H. pylori stool antigen test.
• Patients who did not receive H. pylori eradication regimens before were included in group I of the study (First line eradication regimen).
• Patients who received only one eradication regimen before were included in group II of the study (Second line eradication regimen).
• Patients signing an informed consent.

Exclusion Criteria:

• Patients refusing to sign an informed consent.
• Patients who were on PPIs, P-CABs and/or antibiotics starting one month before inclusion in the study .
• Patients who have chronic debilitating and advanced systemic diseases.
• Patients treated with low dose aspirin and/or non-steroidal anti-inflammatory drugs for a long time.
• Any lactating or pregnant female.