Community members ages 18 - 45 years old from the El Paso, Texas, U.S.-Mexico Border Region will be recruited to compare psychoeducational multimedia interventions focused on the human papillomavirus (HPV). Our hypothesis is that adults who view culturally tailored multimedia stories encouraging HPV vaccination will report higher vaccine uptake rates.

A sample of vaccine-naive (unvaccinated or under-vaccinated) adult community members ages 18 - 45 years old from the El Paso, Texas, U.S.-Mexico Border Region, will be recruited to participate in a human papillomavirus (HPV) multi-media intervention. Hypothesis: Vaccine-eligible adults who view culturally tailored multimedia stories encouraging HPV vaccination will report significantly stronger vaccine intentions and, subsequently, significantly higher vaccine uptake rates when compared to vaccine-eligible adults exposed to a standard HPV vaccination fact sheet and generic HPV vaccine videos.

Inclusion Criteria:

• Adults between the ages 18 and 45 years old
• Adults who have not completed the HPV vaccine series (unvaccinated or under-vaccinated)
• Adults currently living or working in El Paso County, Texas

Exclusion Criteria:

• Adults who participated in Phases I or II of the larger research project [cross-sectional phases]
• Adults younger than 18 years of age
• Adults older than 45 years of age
• Adults that do not reside, plan to live or work in El Paso County, Texas, within the next 12 months after the start of the intervention
• Adults who are unable to participate in the full study intervention and follow-up time-points
• Adults who cannot complete study participation and activities in either the English or Spanish languages.

Collected deidentified individual participant data (IPD), all IPD that underlie results in a publication.

Approximately, starting 6 months-post scholarly publication of previously listed primary and secondary study outcome(s).

Collected deidentified IPD and supporting information will be provided on a case by case basis following a formal request to the University of Texas at El Paso (UTEP) Institutional Review Board (IRB) and subsequent approval by the Principal Investigator.

• Participants [blinding]: participants will be randomly assigned to treatment and control groups, they will not be made aware of other participant's receipt of treatment or control materials. Participants will be asked not to discuss this project outside of the intervention; delivery of the intervention or other educational materials will be virtual, limiting the ability of participants to interact with one another during the study.
• Outcome assessor [blinding]: to reduce bias in the implementation and assessment of the clinical trial, participant information and pre-post survey responses will be maintained separately from the assignment and delivery of the intervention.