A Randomized, Double-blind, Dose-ranging, Placebo-controlled Study to Evaluate the Efficacy and Safety of Bexotegrast (PLN-74809) for the Treatment of Idiopathic Pulmonary Fibrosis (BEACON-IPF)
A Randomized, Double-blind, Dose-ranging, Placebo-controlled Study to Evaluate the Efficacy and Safety of Bexotegrast (PLN-74809) for the Treatment of Idiopathic Pulmonary Fibrosis (BEACON-IPF)
A randomized, double-blind, dose-ranging, placebo-controlled study to evaluate the efficacy and safety of bexotegrast (PLN-74809) for the treatment of idiopathic pulmonary fibrosis (BEACON-IPF).
This is a randomized, double-blind, dose-ranging, placebo-controlled study to evaluate the efficacy and safety of 2 doses of bexotegrast (PLN-74809) [160 and 320 mg] taken for 52 weeks by participants with IPF taking and not taking background therapy (ie, nintedanib or pirfenidone).
The study will consist of an up to 35-day Screening Period, a 52-week Treatment Period, and a 14 day Safety Follow-up Period. Of note, participants who are not taking background therapy at study entry will be allowed to initiate it at any time during the study.
Inclusion Criteria:
Exclusion Criteria:
New Port Beach, California 92663, United States
Sacramento, California 95807, United States
Danbury, Connecticut 06810, United States
New York, New York 10032, United States
Buenos Aires, Buenos Aires F.D. C1425FVH, Argentina
Ciudad Autonoma Buenos Aires, Ciudad Autonoma Buenos Aires 1280, Argentina
Rosario, Santa Fe Province 2000, Argentina
San Miguel de Tucumán, Tucumán Province T4000CBC, Argentina
Porto Alegre, Rio Grande do Sul 90050-170, Brazil
Chengdu, Sichuan 610072, China
Belagavi, Karnataka 590010, India
Ashkelon, Tel Aviv 78278, Israel
Alessandria, Alessandria 15121, Italy
Iizuka-shi, Fukuoka 820-8505, Japan
Kitakyushu-shi, Fukuoka 807-8556, Japan
Naka-gun, Ibaraki 319-1113, Japan
Kawasaki-shi, Kanagawa 216-8511, Japan
Kumagaya-shi, Saitama 360-0197, Japan
Saitama-shi, Saitama 330-8553, Japan
Izumo-shi, Shimane 693-8501, Japan
Hachioji-shi, Tokyo-To 192-0081, Japan
Lisbon, Portugal 1169-024, Portugal