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Introduction: Most cardiovascular diseases (CVD) can be prevented and controlled by adopting lifestyle changes, such as regular physical exercise and nutrition. Resveratrol and beverage extract promote beneficial health effects due to their nutritional properties. Objective: to analyze the effects of resveratrol supplementation and withdrawal extract on post-exercise recovery in coronary heart disease patients. Methods: men diagnosed with ischemic coronary artery disease will undergo four exercise protocols consisting of 30 minutes of aerobic exercise on an ergometric treadmill, with 5 minutes of warm-up, intensity of 30% of the heart rate reserve (HRR), followed by 25 minutes at intensity 60% of FCR and for a final 30 minutes of recovery in the supine position. Before each exercise protocol, all volunteers will consume: 500 mg of placebo (starch), or 500 mg of beetroot, or 500 mg of resveratrol and will also consume resveratrol and drink (500 mg each) 30 minutes before exercise. , the order of each supplementation will be done randomly. Cardiorespiratory parameters and heart rate variability (HRV) will be assessed at different times throughout the experimental procedure. To analyze the moments (rest versus recovery), the Bonferroni post-test will be used for parametric distribution or the Dunn post-test for non-parametric distribution. Statistical significance will be calculated at 5% for all analyses.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo Protocol | Placebo Comparator | exercise and placebo capsules 500 mg (starch) |
|
| Protocol Beet | Experimental | exercise and beet extract 500 mg |
|
| Protocol Resveratrol | Experimental | exercise and resveratrol capsules 500 mg |
|
| Protocol Beet and Resveratrol | Experimental | exercise and beet extract 500mg and resveratrol capsules 500 mg |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Placebo Protocol | Other | ingestion of 500 mg of starch following 30 minutes of exercise (treadmill) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Heart rate variability (HRV) | Time and frequency domain of HRV | through study completion, an average of 1 hour |
| Measure | Description | Time Frame |
|---|---|---|
| Blood Pressure | Systolic Blood Pressure and Diastolic Blood Pressure | through study completion, an average of 1 hour |
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Inclusion Criteria:
Exclusion Criteria:
Volunteers who present at least one of the following characteristics will be excluded:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Universidade Estadual Paulista | Presidente Prudente | São Paulo | 19060-900 | Brazil |
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| Protocol Beet | Other | ingestion of 500 mg of beet extect following 30 minutes of exercise (treadmill) |
|
|
| Protocol Resveratrol | Other | ingestion of 500 mg of resveratrol following 30 minutes of exercise (treadmill) |
|
|
| Protocol Beet and Resveratrol | Other | ingestion 500 mg of beet extect and 500 mg of resveratrol following 30 minutes of exercise (treadmill) |
|
|
| ID | Term |
|---|---|
| D003324 | Coronary Artery Disease |
| ID | Term |
|---|---|
| D003327 | Coronary Disease |
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D001161 | Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
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| ID | Term |
|---|---|
| D013213 | Starch |
| D013395 | Sucrose |
| D000077185 | Resveratrol |
| ID | Term |
|---|---|
| D005936 | Glucans |
| D001704 | Biopolymers |
| D011108 | Polymers |
| D046911 | Macromolecular Substances |
| D004040 | Dietary Carbohydrates |
| D002241 | Carbohydrates |
| D011134 | Polysaccharides |
| D004187 | Disaccharides |
| D009844 | Oligosaccharides |
| D000073893 | Sugars |
| D000081225 | Stilbestrols |
| D013267 | Stilbenes |
| D001597 | Benzylidene Compounds |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |
| D059808 | Polyphenols |
| D010636 | Phenols |
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