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To evaluate the extent to which a 12-week respiratory rehabilitation program consisting of inspiratory and expiratory breathing exercises compared to expiratory breathing exercises alone will help to improve shortness of breath, respiratory symptoms, breathing function, distance walked, and quality of life in those who are experiencing persistent shortness of breath after having had COVID-19. Measurements will take place at the beginning, 6 weeks, and at 12 weeks in the study.
To evaluate the extent to which a 12-week respiratory rehabilitation program consisting of inspiratory and expiratory muscle strength training exercises as compared to a prior study of expiratory muscle strength training alone is effective in improving dyspnea, respiratory symptoms, quantitative measures of pulmonary function, physical performance, and quality of life in individuals reporting persistent dyspnea post-COVID-19 at baseline, six and twelve weeks.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Respiratory Muscle Strength Training | Experimental | Pursed Lip Breathing: Participants will perform two sets of 10 repetitions twice per day. Inspiratory Muscle Strength Training (IMST): The participant will use an IMST trainer provided by the study (Threshold Inspiratory Muscle Strength Trainer). This exercise is repeated for a 3-minute duration, followed by a rest period of 2 minutes. This cycle is repeated for 6 cycles over a 30-minute timespan. This exercise will be performed 3 times/week on alternating days. Expiratory Muscle Strength Training (EMST): The participant will use an EMST trainer (EMST 150) provided by the study. This exercise is repeated for a 3-minute duration, followed by a rest period of 2 minutes. The cycle is repeated for 6 cycles over a 30-minute timespan. This exercise will be performed 3 x/week on opposite days of the inspiratory muscle strength training. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Respiratory Muscle Strength Trainers | Device | Devices provided to each participant. Resistance loading set at less than 50% of the peak inspiratory and peak expiratory flow rate. |
| Measure | Description | Time Frame |
|---|---|---|
| Modified Medical Research Council Scale | Scale of 0-4 with 4 being the most severe dyspnea. | Baseline, 6-weeks, and 12-week measurements |
| COPD Assessment Test | 8-item questionnaire with a semantic, 6-point differential scale for each item. Scores range from 0-40 with higher scores indicating more severe respiratory symptoms. | Baseline, 6-weeks, and 12-week measurements. |
| Forced Expiratory Volume over 1 second (FEV1) | Using the Microlife Digital Peak Flow and FEV1 Meter (Clearwater, FL). | Baseline, 6-weeks, and 12-week measurements |
| Peak Inspiratory Flow | Using the In-Check Peak Inspiratory Flow meter (Granbury, TX). | Baseline, 6-weeks, and 12-week measurements. |
| Thoracic Expansion Measures | Gulick tape measure positioned around the participant's chest at the 4th intercostal space. Participant breathes in and out as far as possible and the difference between the 2 values equals thoracic expansion. | Baseline, 6-weeks, and 12-week measurements |
| Physical Capacity | 6 Minute Walk Test following the American Thoracic Society Procedure: 50-meter distance is marked. Participant walks as quickly as possible for 6 minutes. Results recorded in meters. Vital signs and oxygen saturation monitored and recorded. | Baseline, 6-weeks, and 12-week measurements. |
| EuroQoL-5 Dimension-5 Level |
| Measure | Description | Time Frame |
|---|---|---|
| Feasibility and Acceptability of the Intervention | Recruitment and retention rates. 5-item questionnaire asking participants about the exercise protocol. | 12-weeks. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Constance Visovsky, PhD | University of South Florida | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of South Florida | Tampa | Florida | 33620 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 7154893 | Background | Borg GA. Psychophysical bases of perceived exertion. Med Sci Sports Exerc. 1982;14(5):377-81. | |
| 12091180 | Background | ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories. ATS statement: guidelines for the six-minute walk test. Am J Respir Crit Care Med. 2002 Jul 1;166(1):111-7. doi: 10.1164/ajrccm.166.1.at1102. No abstract available. |
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Data will be available at the end of the study to other investigators and will include the data associated with the study outcomes (Dyspnea, quality of life, pulmonary symptoms, thoracic expansion, pulmonary function tests, six minute walk test, demographics, and feasibility and acceptability).
Data will be available following publication of the study outcomes, and for a period of one year.
A formal request to the primary investigator (Dr. Constance Visovsky).
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| May 14, 2026 | Jun 10, 2026 | 3 | ||
| Jun 23, 2026 |
| ID | Term |
|---|---|
| D000094024 | Post-Acute COVID-19 Syndrome |
| D004417 | Dyspnea |
| D012818 | Signs and Symptoms, Respiratory |
| ID | Term |
|---|---|
| D000086382 | COVID-19 |
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
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Single-group, longitudinal, intervention study
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|
EuroQoL-5 Dimension-5 Level to evaluate 5 dimensions of quality of life including mobility, self-care, usual activities, discomfort and pain, anxiety, and depression. Each is scored using a 5-point semantic scale. |
| Baseline, 6-weeks, and 12-week measurements. |
| 19720809 | Background | Jones PW, Harding G, Berry P, Wiklund I, Chen WH, Kline Leidy N. Development and first validation of the COPD Assessment Test. Eur Respir J. 2009 Sep;34(3):648-54. doi: 10.1183/09031936.00102509. |
| 3342669 | Background | Mahler DA, Wells CK. Evaluation of clinical methods for rating dyspnea. Chest. 1988 Mar;93(3):580-6. doi: 10.1378/chest.93.3.580. |
| 37132243 | Background | Morgan S, Visovsky C, Thomas B, Klein AB, Ji M, Schwab L, Coury J. Home-Based Pilot Pulmonary Program for Dyspneic Patients Post-COVID-19. Clin Nurs Res. 2023 Jun;32(5):895-901. doi: 10.1177/10547738231170496. Epub 2023 May 3. |
| 16942867 | Background | Mota S, Guell R, Barreiro E, Solanes I, Ramirez-Sarmiento A, Orozco-Levi M, Casan P, Gea J, Sanchis J. Clinical outcomes of expiratory muscle training in severe COPD patients. Respir Med. 2007 Mar;101(3):516-24. doi: 10.1016/j.rmed.2006.06.024. Epub 2006 Aug 30. |
| 40995943 | Derived | Morgan SP, Thomas B, Rodriguez CS, Johnson A, Beckie TM. Inspiratory and Expiratory Muscle Strength Training for Persistent Dyspnea in Post-COVID-19. Clin Nurs Res. 2025 Nov;34(8):462-471. doi: 10.1177/10547738251371244. Epub 2025 Sep 25. |
| D007239 |
| Infections |
| D014777 | Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D000094025 | Post-Infectious Disorders |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012120 | Respiration Disorders |
| D012816 | Signs and Symptoms |